Nifedipine is one of the most used calcium channel blocking agents. Due to its low aqueous solubility, it often shows low and irregular bioavailability after oral administration. Nifedipine has short half-life so it has to be administered many times
a day. Immediate-release formulations increase the risk of myocardial infarction and mortality. This research aims to prepare dual-function drug delivery system to enhance nifedipine solubility using solid dispersion technique, and extend its release by incorporating these dispersions in matrix tablets. 32 Factorial design was employed; two independent variables, Poloxamer 188 and Ethyl cellulose, to improve solubility and extend release respectively, were used in 3 levels. The prepared tablets were examined, and succeeded in extending nifedipine release up to 12 hrs. The equations that link the dependent and independent variables were obtained, through which tablet hardness and the released amount after 1, 4 and 6 hours could be predicted.
At this study, two species of genus Equisetum L. have been recorded, that they were: Equisetum telmateia L. and Equisetum ramosissimum Desf.
E. ramosissimum Desf. was recorded for the first time in Lattakia.
The morphological features were used to
separate two species: ( number of the scaly leaves in the node area, shape of the sheath, and number of its teeth, number of the grooves at the stem, length of the strobilus and its color, length of the lateral branches).
This study showed that: the spores had three coats, the exosporium rounded by the
spore like bars with a wide terminal that called: elaters.
Also showed obvious difference in measurements the strobilus and the shapes
of sterile and fertile stem.
At this study, two species of genus Equisetum L. have been recorded, that they were:
Equisetum telmateia L. and Equisetum ramosissimum Desf.
E. ramosissimum Desf. was recorded for the first time in Lattakia.
The morphological features were used to
separate two species: ( number of the scaly
leaves in the node area, shape of the sheath, and number of its teeth, number of the grooves
at the stem, length of the strobilus and its color, length of the lateral branches).
This study showed that: the spores had three coats, the exosporium rounded by the
spore like bars with a wide terminal that called: elaters.
Also showed obvious difference in measurements the strobilus and the shapes
of sterile and fertile stem.
