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Diabetic retinopathy (DR) is one of the most common eye conditions among diabetic patients. However, vision loss occurs primarily in the late stages of DR, and the symptoms of visual impairment, ranging from mild to severe, can vary greatly, adding to the burden of diagnosis and treatment in clinical practice. Deep learning methods based on retinal images have achieved remarkable success in automatic DR grading, but most of them neglect that the presence of diabetes usually affects both eyes, and ophthalmologists usually compare both eyes concurrently for DR diagnosis, leaving correlations between left and right eyes unexploited. In this study, simulating the diagnostic process, we propose a two-stream binocular network to capture the subtle correlations between left and right eyes, in which, paired images of eyes are fed into two identical subnetworks separately during training. We design a contrastive grading loss to learn binocular correlation for five-class DR detection, which maximizes inter-class dissimilarity while minimizing the intra-class difference. Experimental results on the EyePACS dataset show the superiority of the proposed binocular model, outperforming monocular methods by a large margin.
Diabetes is one of the most common disease in individuals. textit{Diabetic retinopathy} (DR) is a complication of diabetes, which could lead to blindness. Automatic DR grading based on retinal images provides a great diagnostic and prognostic value f
Diabetic retinopathy (DR) is a common retinal disease that leads to blindness. For diagnosis purposes, DR image grading aims to provide automatic DR grade classification, which is not addressed in conventional research methods of binary DR image clas
Diabetic retinopathy (DR) is one of the leading causes of blindness. However, no specific symptoms of early DR lead to a delayed diagnosis, which results in disease progression in patients. To determine the disease severity levels, ophthalmologists n
Manually annotating medical images is extremely expensive, especially for large-scale datasets. Self-supervised contrastive learning has been explored to learn feature representations from unlabeled images. However, unlike natural images, the applica
Assessing the degree of disease severity in biomedical images is a task similar to standard classification but constrained by an underlying structure in the label space. Such a structure reflects the monotonic relationship between different disease g