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تسجيل مستخدم جديدDeep Learning Captures More Accurate Diffusion Fiber Orientations Distributions than Constrained Spherical Deconvolution
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Confocal histology provides an opportunity to establish intra-voxel fiber orientation distributions that can be used to quantitatively assess the biological relevance of diffusion weighted MRI models, e.g., constrained spherical deconvolution (CSD). Here, we apply deep learning to investigate the potential of single shell diffusion weighted MRI to explain histologically observed fiber orientation distributions (FOD) and compare the derived deep learning model with a leading CSD approach. This study (1) demonstrates that there exists additional information in the diffusion signal that is not currently exploited by CSD, and (2) provides an illustrative data-driven model that makes use of this information.
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Diffusion-weighted magnetic resonance imaging (DW-MRI) is the only non-invasive approach for estimation of intra-voxel tissue microarchitecture and reconstruction of in vivo neural pathways for the human brain. With improvement in accelerated MRI acq
uisition technologies, DW-MRI protocols that make use of multiple levels of diffusion sensitization have gained popularity. A well-known advanced method for reconstruction of white matter microstructure that uses multi-shell data is multi-tissue constrained spherical deconvolution (MT-CSD). MT-CSD substantially improves the resolution of intra-voxel structure over the traditional single shell version, constrained spherical deconvolution (CSD). Herein, we explore the possibility of using deep learning on single shell data (using the b=1000 s/mm2 from the Human Connectome Project (HCP)) to estimate the information content captured by 8th order MT-CSD using the full three shell data (b=1000, 2000, and 3000 s/mm2 from HCP). Briefly, we examine two network architectures: 1.) Sequential network of fully connected dense layers with a residual block in the middle (ResDNN), 2.) Patch based convolutional neural network with a residual block (ResCNN). For both networks an additional output block for estimation of voxel fraction was used with a modified loss function. Each approach was compared against the baseline of using MT-CSD on all data on 15 subjects from the HCP divided into 5 training, 2 validation, and 8 testing subjects with a total of 6.7 million voxels. The fiber orientation distribution function (fODF) can be recovered with high correlation (0.77 vs 0.74 and 0.65) as compared to the ground truth of MT-CST, which was derived from the multi-shell DW-MRI acquisitions. Source code and models have been made publicly available.
Purpose: To propose a deep learning-based reconstruction framework for ultrafast and robust diffusion tensor imaging and fiber tractography. Methods: We propose SuperDTI to learn the nonlinear relationship between diffusion-weighted images (DWIs) and
the corresponding tensor-derived quantitative maps as well as the fiber tractography. Super DTI bypasses the tensor fitting procedure, which is well known to be highly susceptible to noise and motion in DWIs. The network is trained and tested using datasets from Human Connectome Project and patients with ischemic stroke. SuperDTI is compared against the state-of-the-art methods for diffusion map reconstruction and fiber tracking. Results: Using training and testing data both from the same protocol and scanner, SuperDTI is shown to generate fractional anisotropy and mean diffusivity maps, as well as fiber tractography, from as few as six raw DWIs. The method achieves a quantification error of less than 5% in all regions of interest in white matter and gray matter structures. We also demonstrate that the trained neural network is robust to noise and motion in the testing data, and the network trained using healthy volunteer data can be directly applied to stroke patient data without compromising the lesion detectability. Conclusion: This paper demonstrates the feasibility of superfast diffusion tensor imaging and fiber tractography using deep learning with as few as six DWIs directly, bypassing tensor fitting. Such a significant reduction in scan time may allow the inclusion of DTI into the clinical routine for many potential applications.
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