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تسجيل مستخدم جديدInference for stochastic kinetic models from multiple data sources for joint estimation of infection dynamics from aggregate reports and virological data
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Influenza and respiratory syncytial virus (RSV) are the leading etiological agents of seasonal acute respiratory infections (ARI) around the world. Medical doctors typically base the diagnosis of ARI on patients symptoms alone and do not always conduct virological tests necessary to identify individual viruses, which limits the ability to study the interaction between multiple pathogens and make public health recommendations. We consider a stochastic kinetic model (SKM) for two interacting ARI pathogens circulating in a large population and an empirically motivated background process for infections with other pathogens causing similar symptoms. An extended marginal sampling approach based on the Linear Noise Approximation to the SKM integrates multiple data sources and additional model components. We infer the parameters defining the pathogens dynamics and interaction within a Bayesian hierarchical model and explore the posterior trajectories of infections for each illness based on aggregate infection reports from six epidemic seasons collected by the state health department, and a subset of virological tests from a sentinel program at a general hospital in San Luis Potosi, Mexico. We interpret the results based on real and simulated data and make recommendations for future data collection strategies. Supplementary materials and software are provided online.
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Influenza and respiratory syncytial virus (RSV) are the leading etiological agents of seasonal acute respiratory infections (ARI) around the world. Medical doctors typically base the diagnosis of ARI on patients symptoms alone, and do not always cond
uct virological tests necessary to identify individual viruses, which limits the ability to study the interaction between multiple pathogens and make public health recommendations. We consider a stochastic kinetic model (SKM) for two interacting ARI pathogens circulating in a large population and an empirically motivated background process for infections with other pathogens causing similar symptoms. An extended marginal sampling approach based on the Linear Noise Approximation to the SKM integrates multiple data sources and additional model components. We infer the parameters defining the pathogens dynamics and interaction within a Bayesian hierarchical model and explore the posterior trajectories of infections for each illness based on aggregate infection reports from six epidemic seasons collected by the state health department, and a subset of virological tests from a sentinel program at a general hospital in San Luis Potosi, Mexico. We interpret the results based on real and simulated data and make recommendations for future data collection strategies. Supplementary materials and software are provided online.
All pandemics are local; so learning about the impacts of pandemics on public health and related societal issues at granular levels is of great interest. COVID-19 is affecting everyone in the globe and mask wearing is one of the few precautions again
st it. To quantify peoples perception of mask effectiveness and to prevent the spread of COVID-19 for small areas, we use Understanding America Studys (UAS) survey data on COVID-19 as our primary data source. Our data analysis shows that direct survey-weighted estimates for small areas could be highly unreliable. In this paper we develop a synthetic estimation method to estimate proportions of mask effectiveness for small areas using a logistic model that combines information from multiple data sources. We select our working model using an extensive data analysis facilitated by a new variable selection criterion for survey data and benchmarking ratios. We propose a Jackknife method to estimate variance of our proposed estimator. From our data analysis. it is evident that our proposed synthetic method outperforms direct survey-weighted estimator with respect to commonly used evaluation measures.
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While it is well known that high levels of prenatal alcohol exposure (PAE) result in significant cognitive deficits in children, the exact nature of the dose response is less well understood. In particular, there is a pressing need to identify the le
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