ترغب بنشر مسار تعليمي؟ اضغط هنا

Non-identifiability of parameters for a class of shear-thinning rheological models, with implications for haematological fluid dynamics

47   0   0.0 ( 0 )
 نشر من قبل Meurig Thomas Gallagher
 تاريخ النشر 2018
  مجال البحث فيزياء علم الأحياء
والبحث باللغة English




اسأل ChatGPT حول البحث

Choosing a suitable model and determining its associated parameters from fitting to experimental data is fundamental for many problems in biomechanics. Models of shear-thinning complex fluids, dating from the work of Bird, Carreau, Cross and Yasuda, have been applied in highly-cited computational studies of heamodynamics for several decades. In this manuscript we revisit these models, first to highlight a degree of uncertainty in the naming conventions in the literature, but more importantly to address the problem of inferring model parameters by fitting rheology experiments. By refitting published data, and also by simulation, we find large, flat regions in likelihood surfaces that yield families of parameter sets which fit the data equally well. Despite having almost indistinguishable fits to experimental data these varying parameter sets can predict very different flow profiles, and as such these parameters cannot be used to draw conclusions about physical properties of the fluids, such as zero-shear viscosity or relaxation time of the fluid, or indeed flow behaviours. We verify that these features are not a consequence of the experimental data sets through simulations; by sampling points from the rheological models and adding a small amount of noise we create a synthetic data set which reveals that the problem of parameter identifiability is intrinsic to these models.



قيم البحث

اقرأ أيضاً

Exact solutions for laminar stratified flows of Newtonian/non-Newtonian shear-thinning fluids in horizontal and inclined channels are presented. An iterative algorithm is proposed to compute the laminar solution for the general case of a Carreau non- Newtonian fluid. The exact solution is used to study the effect of the rheology of the shear-thinning liquid on two-phase flow characteristics considering both gas/liquid and liquid/liquid systems. Concurrent and counter-current inclined systems are investigated, including the mapping of multiple solution boundaries. Aspects relevant to practical applications are discussed, such as the insitu hold-up, or lubrication effects achieved by adding a less viscous phase. A characteristic of this family of systems is that, even if the liquid has a complex rheology (Carreau fluid), the two-phase stratified flow can behave like the liquid is Newtonian for a wide range of operational conditions. The capability of the two-fluid model to yield satisfactory predictions in the presence of shear-thinning liquids is tested, and an algorithm is proposed to a priori predict if the Newtonian (zero shear rate viscosity) behaviour arises for a given operational conditions in order to avoid large errors in the predictions of flow characteristics when the power-law is considered for modelling the shear-thinning behaviour. Two-fluid model closures implied by the exact solution and the effect of a turbulent gas layer are also addressed.
Instability mechanism based on Coriolis force, on a rapidly rotating portable device handling shear thinning fluids such as blood, is of utmost importance for eventual detection of diseases by mixing with the suitable reagents. Motivated by this prop osition, the present study renders a modal stability analysis of shear thinning fluids in a rotating microchannel modelled by the Carreau rheological law. When a microchannel is engraved a rotating compact disc (CD) based device, the centrifugal force acts as the driving force that actuates the flow and the Coriolis force enhances the mixing process in significantly short span by destabilizing the flow. An OrrSommerfeld-Squire analysis is performed to explore the role of these forces on the linear stability of rotating shear-thinning flow. Reported results on shear thinning flow with streamwise disturbances indicate that the critical Reynolds number for the flow transition with viscosity perturbation is nearly half of that of the critical value for the same without viscosity perturbation. In sharp contrast, the present analysis considering spanwise disturbances reveals that the critical Reynolds numbers with and without viscosity perturbation remain virtually unaltered under rotational effects. However, the viscosity variation has no significant influence on the Coriolis force-based instability. Numerical results confirm that a momentous destabilization is possible by aid of the Coriolis force via generating secondary flow inside the channel. Interestingly, the roll cells corresponding to the instabilities at lower time constants exhibit the existence of two distinct vortices, and the centre of the stronger one is essentially settled towards the unstable stratified region. Moreover, for a higher value of the time constant, only one vortex occupies the entire channel.
Linear stability of horizontal and inclined stratified channel flows of Newtonian/non-Newtonian shear-thinning fluids is investigated with respect to all wavelength perturbations. The Carreau model has been chosen for the modeling of the rheology of a shear-thinning fluid, owing to its capability to describe properly the constant viscosity limits (Newtonian behavior) at low and high shear rates. The results are presented in the form of stability boundaries on flow pattern maps (with the phases superficial velocities as coordinates) for several practically important gas-liquid and liquid-liquid systems. The stability maps are accompanied by spatial profiles of the critical perturbations, along with the distributions of the effective and tangent viscosities in the non-Newtonian layer, to show the influence of the complex rheological behavior of shear-thinning liquids on the mechanisms responsible for triggering instability. Due to the complexity of the considered problem, a working methodology is proposed to alleviate the search for the stability boundary. Implementation of the proposed methodology helps to reveal that in many cases the investigation of the simpler Newtonian problem is sufficient for the prediction of the exact (non-Newtonian) stability boundary of smooth stratified flow (i.e., in case of horizontal gas-liquid flow). Therefore, the knowledge gained from the stability analysis of Newtonian fluids is applicable to those (usually highly viscous) non-Newtonian systems. Since the stability of stratified flow involving highly viscous Newtonian liquids has not been researched in the literature, interesting findings on the viscosity effects are also obtained.
We analyze transient dynamics during shear start-up in viscoelastic flows between two parallel plates, with a specific focus on the signatures for the onset of transient shear banding using the Johnson-Segalman, non-stretching Rolie-Poly and Giesekus models. We explore the dynamics of shear start-up in monotonic regions of the constitutive curves using two different methodologies: (i) the oft-used `frozen-time linear stability (eigenvalue) analysis, wherein we examine whether infinitesimal perturbations imposed on instantaneous stress components (treated as quasi steady states) exhibit exponential growth, and (ii) the more mathematically rigorous fundamental-matrix approach that characterizes the transient growth via a numerical solution of the time-dependent linearized governing equations, wherein the linearized perturbations co-evolve with the start-up shear flow. Our results reinforce the hitherto understated point that there is no universal connection between the overshoot and subsequent decay of shear stress in the base state and the unstable eigenvalues obtained from the frozen-time stability analysis. It may therefore be difficult to subsume the occurrence of transient shear banding during shear start-up within the ambit of a single model-independent criterion. Our work also suggests that the strong transients during shear start-up seen in earlier work could well be a consequence of consideration of the limit of small solvent viscosity in the absence of otherwise negligible terms such as fluid inertia.
Truncated Taylor expansions of smooth flow maps are used in Hamiltons principle to derive a multiscale Lagrangian particle representation of ideal fluid dynamics. Numerical simulations for scattering of solutions at one level of truncation are found to produce solutions at higher levels. These scattering events to higher levels in the Taylor expansion are interpreted as modeling a cascade to smaller scales.
التعليقات
جاري جلب التعليقات جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا