اشترك بالحزمة الذهبية واحصل على وصول غير محدود شمرا أكاديميا
تسجيل مستخدم جديدReduction of Mathematical Models of Nuclear Receptor Binding to Promoter Regions
118
0
0.0
(
0
)
تأليف
Sarbaz H. A. Khoshnaw
اسأل ChatGPT حول البحث
ﻻ يوجد ملخص باللغة العربية
We study kinetic model of Nuclear Receptor Binding to Promoter Regions. This model is written as a system of ordinary differential equations. Model reduction techniques have been used to simplify chemical kinetics.In this case study, the technique of Pseudo-first order approximation is applied to simplify the reaction rates. CellDesigner has been used to draw the structures of chemical reactions of Nuclear Receptor Binding to Promoter Regions. After model reduction, the general analytical solution for reduced model is given and the number of species and reactions are reduced from 9 species and 6 reactions to 6 species and 5 reactions.
قيم البحث
اقرأ أيضاً
Infection by many viruses begins with fusion of viral and cellular lipid membranes, followed by entry of viral contents into the target cell and ultimately, after many biochemical steps, integration of viral DNA into that of the host cell. The early
steps of membrane fusion and viral capsid entry are mediated by adsorption to the cell surface, and receptor and coreceptor binding. HIV-1 specifically targets CD4+ helper T-cells of the human immune system and binds to the receptor CD4 and coreceptor CCR5 before fusion is initiated. Previous experiments have been performed using a cell line (293-Affinofile) in which the expression of CD4 and CCR5 concentration were independently controlled. After exposure to HIV-1 of various strains, the resulting infectivity was measured through the fraction of infected cells. To design and evaluate the effectiveness of drug therapies that target the inhibition of the entry processes, an accurate functional relationship between the CD4/CCR5 concentrations and infectivity is desired in order to more quantitatively analyze experimental data. We propose three kinetic models describing the possible mechanistic processes involved in HIV entry and fit their predictions to infectivity measurements, contrasting and comparing different outcomes. Our approach allows interpretation of the clustering of infectivity of different strains of HIV-1 in the space of mechanistic kinetic parameters. Our model fitting also allows inference of nontrivial stoichiometries of receptor and coreceptor binding and provides a framework through which to quantitatively investigate the effectiveness of fusion inhibitors and neutralizing antibodies.
Rule-based modeling is a powerful way to model kinetic interactions in biochemical systems. Rules enable a precise encoding of biochemical interactions at the resolution of sites within molecules, but obtaining an integrated global view from sets of
rules remains challenging. Current automated approaches to rule visualization fail to address the complexity of interactions between rules, limiting either the types of rules that are allowed or the set of interactions that can be visualized simultaneously. There is a need for scalable visualization approaches that present the information encoded in rules in an intuitive and useful manner at different levels of detail. We have developed new automated approaches for visualizing both individual rules and complete rule-based models. We find that a more compact representation of an individual rule promotes promotes understanding the model assumptions underlying each rule. For global visualization of rule interactions, we have developed a method to synthesize a network of interactions between sites and processes from a rule-based model and then use a combination of user-defined and automated approaches to compress this network into a readable form. The resulting diagrams enable modelers to identify signaling motifs such as cascades, feedback loops, and feed-forward loops in complex models, as we demonstrate using several large-scale models. These capabilities are implemented within the BioNetGen framework but the approach is equally applicable to rule-based models specified in other formats.
In this paper I have given a mathematical model of Cell reprogramming from a different contexts. Here I considered there is a delay in differential regulator rate equations due to intermediate regulators regulations. At first I gave some basic mathem
atical models by Ferell Jr.[2] of reprogramming and after that I gave mathematical model of cell reprogramming by Mithun Mitra[4]. In the last section I contributed a mathematical model of cell reprogramming from intermediate steps regulations and tried to find the critical point of pluripotent cell.
The work reported here aims to address the effects of time-dependent parameters and stochasticity on decision-making in biological systems. We achieve this by extending previous studies that resorted to simple normal forms. Yet, we focus primarily on
the issue of the systems sensitivity to initial conditions in the presence of different noise distributions. In addition, we assess the impact of two-way sweeping through the critical region of a canonical Pitchfork bifurcation with a constant external asymmetry. The parallel with decision-making in bio-circuits is performed on this simple system since it is equivalent in its available states and dynamics to more complex genetic circuits. Overall, we verify that rate-dependent effects are specific to particular initial conditions. Information processing for each starting state is affected by the balance between sweeping speed through critical regions, and the type of fluctuations added. For a heavy-tail noise, forward-reverse dynamic bifurcations are more efficient in processing the information contained in external signals, when compared to the system relying on escape dynamics, if it starts at an attractor not favoured by the asymmetry and, in conjunction, if the sweeping amplitude is large.
Most biological processes are described as a series of interactions between proteins and other molecules, and interactions are in turn described in terms of atomic structures. To annotate protein functions as sets of interaction states at atomic reso
lution, and thereby to better understand the relation between protein interactions and biological functions, we conducted exhaustive all-against-all atomic structure comparisons of all known binding sites for ligands including small molecules, proteins and nucleic acids, and identified recurring elementary motifs. By integrating the elementary motifs associated with each subunit, we defined composite motifs which represent context-dependent combinations of elementary motifs. It is demonstrated that function similarity can be better inferred from composite motif similarity compared to the similarity of protein sequences or of individual binding sites. By integrating the composite motifs associated with each protein function, we define meta-composite motifs each of which is regarded as a time-independent diagrammatic representation of a biological process. It is shown that meta-composite motifs provide richer annotations of biological processes than sequence clusters. The present results serve as a basis for bridging atomic structures to higher-order biological phenomena by classification and integration of binding site structures.
سجل دخول لتتمكن من نشر تعليقات
التعليقات
جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
