ترغب بنشر مسار تعليمي؟ اضغط هنا

Exclusion processes on networks as models for cytoskeletal transport

124   0   0.0 ( 0 )
 نشر من قبل Izaak Neri
 تاريخ النشر 2013
  مجال البحث فيزياء
والبحث باللغة English




اسأل ChatGPT حول البحث

We present a study of exclusion processes on networks as models for complex transport phenomena and in particular for active transport of motor proteins along the cytoskeleton. We argue that active transport processes on networks spontaneously develop density heterogeneities at various scales. These heterogeneities can be regulated through a variety of multi-scale factors, such as the interplay of exclusion interactions, the non-equilibrium nature of the transport process and the network topology. We show how an effective rate approach allows to develop an understanding of the stationary state of transport processes through complex networks from the phase diagram of one single segment. For exclusion processes we rationalize that the stationary state can be classified in three qualitatively different regimes: a homogeneous phase as well as inhomogeneous network and segment phases. In particular, we present here a study of the stationary state on networks of three paradigmatic models from non-equilibrium statistical physics: the totally asymmetric simple exclusion process, the partially asymmetric simple exclusion process and the totally asymmetric simple exclusion process with Langmuir kinetics. With these models we can interpolate between equilibrium (due to bi-directional motion along a network or infinite diffusion) and out-of-equilibrium active directed motion along a network. The study of these models sheds further light on the emergence of density heterogeneities in active phenomena.



قيم البحث

اقرأ أيضاً

The dynamics of pedestrian crowds has been studied intensively in recent years, both theoretically and empirically. However, in many situations pedestrian crowds are rather static, e.g. due to jamming near bottlenecks or queueing at ticket counters o r supermarket checkouts. Classically such queues are often described by the M/M/1 queue that neglects the internal structure (density profile) of the queue by focussing on the system length as the only dynamical variable. This is different in the Exclusive Queueing Process (EQP) in which the queue is considered on a microscopic level. It is equivalent to a Totally Asymmetric Exclusion Process (TASEP) of varying length. The EQP has a surprisingly rich phase diagram with respect to the arrival probability alpha and the service probability beta. The behavior on the phase transition line is much more complex than for the TASEP with a fixed system length. It is nonuniversal and depends strongly on the update procedure used. In this article, we review the main properties of the EQP. We also mention extensions and applications of the EQP and some related models.
515 - Sarah A. Nowak , Pak-Wing Fok , 2007
We investigate the dynamics of a one-dimensional asymmetric exclusion process with Langmuir kinetics and a fluctuating wall. At the left boundary, particles are injected onto the lattice; from there, the particles hop to the right. Along the lattice, particles can adsorb or desorb, and the right boundary is defined by a wall particle. The confining wall particle has intrinsic forward and backward hopping, a net leftward drift, and cannot desorb. Performing Monte Carlo simulations and using a moving-frame finite segment approach coupled to mean field theory, we find the parameter regimes in which the wall acquires a steady state position. In other regimes, the wall will either drift to the left and fall off the lattice at the injection site, or drift indefinitely to the right. Our results are discussed in the context of non-equilibrium phases of the system, fluctuating boundary layers, and particle densities in the lab frame versus the frame of the fluctuating wall.
We study seasonal epidemic spreading in a susceptible-infected-removed-susceptible (SIRS) model on smallworld graphs. We derive a mean-field description that accurately captures the salient features of the model, most notably a phase transition betwe en annual and biennial outbreaks. A numerical scaling analysis exhibits a diverging autocorrelation time in the thermodynamic limit, which confirms the presence of a classical discrete time crystalline phase. We derive the phase diagram of the model both from mean-field theory and from numerics. Our work offers new perspectives by demonstrating that small-worldness and non-Markovianity can stabilize a classical discrete time crystal, and by linking recent efforts to understand such dynamical phases of matter to the century-old problem of biennial epidemics.
We consider the dynamics of fluctuations in the quantum asymmetric simple exclusion process (Q-ASEP) with periodic boundary conditions. The Q-ASEP describes a chain of spinless fermions with random hoppings that are induced by a Markovian environment . We show that fluctuations of the fermionic degrees of freedom obey evolution equations of Lindblad type, and derive the corresponding Lindbladians. We identify the underlying algebraic structure by mapping them to non-Hermitian spin chains and demonstrate that the operator space fragments into exponentially many (in system size) sectors that are invariant under time evolution. At the level of quadratic fluctuations we consider the Lindbladian on the sectors that determine the late time dynamics for the particular case of the quantum symmetric simple exclusion process (Q-SSEP). We show that the corresponding blocks in some cases correspond to known Yang-Baxter integrable models and investigate the level-spacing statistics in others. We carry out a detailed analysis of the steady states and slow modes that govern the late time behaviour and show that the dynamics of fluctuations of observables is described in terms of closed sets of coupled linear differential-difference equations. The behaviour of the solutions to these equations is essentially diffusive but with relevant deviations, that at sufficiently late times and large distances can be described in terms of a continuum scaling limit which we construct. We numerically check the validity of this scaling limit over a significant range of time and space scales. These results are then applied to the study of operator spreading at large scales, focusing on out-of-time ordered correlators and operator entanglement.
207 - D. A. Quint , J. M. Schwarz 2010
Actin cytoskeletal protrusions in crawling cells, or lamellipodia, exhibit various morphological properties such as two characteristic peaks in the distribution of filament orientation with respect to the leading edge. To understand these properties, using the dendritic nucleation model as a basis for cytoskeletal restructuring, a kinetic-population model with orientational-dependent branching (birth) and capping (death) is constructed and analyzed. Optimizing for growth yields a relation between the branch angle and filament orientation that explains the two characteristic peaks. The model also exhibits a subdominant population that allows for more accurate modeling of recent measurements of filamentous actin density along the leading edge of lamellipodia in keratocytes. Finally, we explore the relationship between orientational and spatial organization of filamentous actin in lamellipodia and address recent observations of a prevalence of overlapping filaments to branched filaments---a finding that is claimed to be in contradiction with the dendritic nucleation model.
التعليقات
جاري جلب التعليقات جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا