اشترك بالحزمة الذهبية واحصل على وصول غير محدود شمرا أكاديميا
تسجيل مستخدم جديدShape diagram of vesicles in Poiseuille flow
192
0
0.0
(
0
)
اسأل ChatGPT حول البحث
ﻻ يوجد ملخص باللغة العربية
Soft bodies flowing in a channel often exhibit parachute-like shapes usually attributed to an increase of hydrodynamic constraint (viscous stress and/or confinement). We show that the presence of a fluid membrane leads to the reverse phenomenon and build a phase diagram of shapes --- which are classified as bullet, croissant and parachute --- in channels of varying aspect ratio. Unexpectedly, shapes are relatively wider in the narrowest direction of the channel. We highlight the role of flow patterns on the membrane in this response to the asymmetry of stress distribution.
قيم البحث
اقرأ أيضاً
We study the flow of membranal fluid through a ring of immobile particles mimicking, for example, a fence around a membrane corral. We obtain a simple closed-form expression for the permeability coefficient of the ring as a function of the particles
line fraction. The analytical results agree with those of numerical calculations and are found to be robust against changes in particle number and corral shape. From the permeability results we infer the collective diffusion coefficient of lipids through the ring and discuss possible implications for collective lipid transport in a crowded membrane.
Complex interactions between cellular systems and their surrounding extracellular matrices are emerging as important mechanical regulators of cell functions such as proliferation, motility, and cell death, and such cellular systems are often characte
rized by pulsating acto-myosin activities. Here, using an active gel model, we numerically explore the spontaneous flow generation by activity pulses in the presence of a viscoelastic medium. The results show that cross-talk between the activity-induced deformations of the viscoelastic surroundings with the time-dependent response of the active medium to these deformations can lead to the reversal of spontaneously generated active flows. We explain the mechanism behind this phenomenon based on the interaction between the active flow and the viscoelastic medium. We show the importance of relaxation timescales of both the polymers and the active particles and provide a phase-space over which such spontaneous flow reversals can be observed. Our results suggest new experiments investigating the role of controlled pulses of activity in living systems ensnared in complex mircoenvironments.
Unravelling the physical mechanisms behind the organisation of lipid domains is a central goal in cell biology and membrane biophysics. Previous studies on cells and model lipid bilayers featuring phase-separated domains found an intricate interplay
between the membrane geometry and its chemical composition. However, the lack of a model system with simultaneous control over the membrane shape and conservation of its composition precluded a fundamental understanding of curvature-induced effects. Here, we present a new class of multicomponent vesicles supported by colloidal scaffolds of designed shape. We find that the domain composition adapts to the geometry, giving rise to a novel antimixed state. Theoretical modelling allowed us to link the pinning of domains by regions of high curvature to the material parameters of the membrane. Our results provide key insights into the phase separation of cellular membranes and on curved surfaces in general.
Many biological systems fold thin sheets of lipid membrane into complex three-dimensional structures. This microscopic origami is often mediated by the adsorption and self-assembly of proteins on a membrane. As a model system to study adsorption-medi
ated interactions, we study the collective behavior of micrometric particles adhered to a lipid vesicle. We estimate the colloidal interactions using a maximum likelihood analysis of particle trajectories. When the particles are highly wrapped by a tense membrane, we observe strong long-range attractions with a typical binding energy of 150 $k_B T$ and significant forces extending a few microns.
While the behavior of vesicles in thermodynamic equilibrium has been studied extensively, how active forces control vesicle shape transformations is not understood. Here, we combine theory and simulations to study the shape behavior of vesicles conta
ining active Brownian particles. We show that the combination of active forces, dimensionality and membrane bending free energy creates a plethora of novel phase transitions. At low swim pressure, the vesicle exhibits a discontinuous transition from a spherical to a prolate shape, which has no counterpart in two dimensions. At high swim pressure it exhibits stochastic spatio-temporal oscillations. Our work helps to understand and control the shape dynamics of membranes in active-matter systems.
سجل دخول لتتمكن من نشر تعليقات
التعليقات
جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
