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We describe the distribution of Guanine and Cytosine (GC) content in the third codon position (GC3) distributions in different species, analyze evolutionary trends and discuss differences between genes and organisms with distinct GC3 levels. We scrutinize previously published theoretical frameworks and construct a unified view of GC3 biology in eukaryotes and prokaryotes.
Innovation in synthetic biology often still depends on large-scale experimental trial-and-error, domain expertise, and ingenuity. The application of rational design engineering methods promise to make this more efficient, faster, cheaper and safer. B
Possibilities for using geometry and topology to analyze statistical problems in biology raise a host of novel questions in geometry, probability, algebra, and combinatorics that demonstrate the power of biology to influence the future of pure mathem
Randomness is an unavoidable feature of the intracellular environment due to chemical reactants being present in low copy number. That phenomenon, predicted by Delbruck long ago cite{delbruck40}, has been detected in both prokaryotic cite{elowitz02,c
We present a new experimental-computational technology of inferring network models that predict the response of cells to perturbations and that may be useful in the design of combinatorial therapy against cancer. The experiments are systematic series