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Possibilities for using geometry and topology to analyze statistical problems in biology raise a host of novel questions in geometry, probability, algebra, and combinatorics that demonstrate the power of biology to influence the future of pure mathematics. This expository article is a tour through some biological explorations and their mathematical ramifications. The article starts with evolution of novel topological features in wing veins of fruit flies, which are quantified using the algebraic structure of multiparameter persistent homology. The statistical issues involved highlight mathematical implications of sampling from moduli spaces. These lead to geometric probability on stratified spaces, including the sticky phenomenon for Frechet means and the origin of this mathematical area in the reconstruction of phylogenetic trees.
Antimicrobial resistance is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050. Research over the last decade has demonstrated that the
Computer simulations have become an important tool across the biomedical sciences and beyond. For many important problems several different models or hypotheses exist and choosing which one best describes reality or observed data is not straightforwa
Synthetic biology is the engineering of cellular networks. It combines principles of engineering and the knowledge of biological networks to program the behavior of cells. Computational modeling techniques in conjunction with molecular biology techni
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Cellular heterogeneity is an immanent property of biological systems that covers very different aspects of life ranging from genetic diversity to cell-to-cell variability driven by stochastic molecular interactions, and noise induced cell differentia