Holographic displays can generate light fields by dynamically modulating the wavefront of a coherent beam of light using a spatial light modulator, promising rich virtual and augmented reality applications. However, the limited spatial resolution of
existing dynamic spatial light modulators imposes a tight bound on the diffraction angle. As a result, todays holographic displays possess low {e}tendue, which is the product of the display area and the maximum solid angle of diffracted light. The low {e}tendue forces a sacrifice of either the field of view (FOV) or the display size. In this work, we lift this limitation by presenting neural {e}tendue expanders. This new breed of optical elements, which is learned from a natural image dataset, enables higher diffraction angles for ultra-wide FOV while maintaining both a compact form factor and the fidelity of displayed contents to human viewers. With neural {e}tendue expanders, we achieve 64$times$ {e}tendue expansion of natural images with reconstruction quality (measured in PSNR) over 29dB on simulated retinal-resolution images. As a result, the proposed approach with expansion factor 64$times$ enables high-fidelity ultra-wide-angle holographic projection of natural images using an 8K-pixel SLM, resulting in a 18.5 mm eyebox size and 2.18 steradians FOV, covering 85% of the human stereo FOV.
We analyze the spaces of images encoded by generative networks of the BigGAN architecture. We find that generic multiplicative perturbations away from the photo-realistic point often lead to images which appear as artistic renditions of the correspon
ding objects. This demonstrates an emergence of aesthetic properties directly from the structure of the photo-realistic environment coupled with its neural network parametrization. Moreover, modifying a deep semantic part of the neural network encoding leads to the appearance of symbolic visual representations.
Text detection in natural scene images for content analysis is an interesting task. The research community has seen some great developments for English/Mandarin text detection. However, Urdu text extraction in natural scene images is a task not well
addressed. In this work, firstly, a new dataset is introduced for Urdu text in natural scene images. The dataset comprises of 500 standalone images acquired from real scenes. Secondly, the channel enhanced Maximally Stable Extremal Region (MSER) method is applied to extract Urdu text regions as candidates in an image. Two-stage filtering mechanism is applied to eliminate non-candidate regions. In the first stage, text and noise are classified based on their geometric properties. In the second stage, a support vector machine classifier is trained to discard non-text candidate regions. After this, text candidate regions are linked using centroid-based vertical and horizontal distances. Text lines are further analyzed by a different classifier based on HOG features to remove non-text regions. Extensive experimentation is performed on the locally developed dataset to evaluate the performance. The experimental results show good performance on test set images. The dataset will be made available for research use. To the best of our knowledge, the work is the first of its kind for the Urdu language and would provide a good dataset for free research use and serve as a baseline performance on the task of Urdu text extraction.
In this work, we present Eformer - Edge enhancement based transformer, a novel architecture that builds an encoder-decoder network using transformer blocks for medical image denoising. Non-overlapping window-based self-attention is used in the transf
ormer block that reduces computational requirements. This work further incorporates learnable Sobel-Feldman operators to enhance edges in the image and propose an effective way to concatenate them in the intermediate layers of our architecture. The experimental analysis is conducted by comparing deterministic learning and residual learning for the task of medical image denoising. To defend the effectiveness of our approach, our model is evaluated on the AAPM-Mayo Clinic Low-Dose CT Grand Challenge Dataset and achieves state-of-the-art performance, $i.e.$, 43.487 PSNR, 0.0067 RMSE, and 0.9861 SSIM. We believe that our work will encourage more research in transformer-based architectures for medical image denoising using residual learning.
Cine cardiac MRI is routinely acquired for the assessment of cardiac health, but the imaging process is slow and typically requires several breath-holds to acquire sufficient k-space profiles to ensure good image quality. Several undersampling-based
reconstruction techniques have been proposed during the last decades to speed up cine cardiac MRI acquisition. However, the undersampling factor is commonly fixed to conservative values before acquisition to ensure diagnostic image quality, potentially leading to unnecessarily long scan times. In this paper, we propose an end-to-end quality-aware cine short-axis cardiac MRI framework that combines image acquisition and reconstruction with downstream tasks such as segmentation, volume curve analysis and estimation of cardiac functional parameters. The goal is to reduce scan time by acquiring only a fraction of k-space data to enable the reconstruction of images that can pass quality control checks and produce reliable estimates of cardiac functional parameters. The framework consists of a deep learning model for the reconstruction of 2D+t cardiac cine MRI images from undersampled data, an image quality-control step to detect good quality reconstructions, followed by a deep learning model for bi-ventricular segmentation, a quality-control step to detect good quality segmentations and automated calculation of cardiac functional parameters. To demonstrate the feasibility of the proposed approach, we perform simulations using a cohort of selected participants from the UK Biobank (n=270), 200 healthy subjects and 70 patients with cardiomyopathies. Our results show that we can produce quality-controlled images in a scan time reduced from 12 to 4 seconds per slice, enabling reliable estimates of cardiac functional parameters such as ejection fraction within 5% mean absolute error.
Artificial Intelligence (AI) can potentially support histopathologists in the diagnosis of a broad spectrum of cancer types. In colorectal cancer (CRC), AI can alleviate the laborious task of characterization and reporting on resected biopsies, inclu
ding polyps, the numbers of which are increasing as a result of CRC population screening programs, ongoing in many countries all around the globe. Here, we present an approach to address two major challenges in automated assessment of CRC histopathology whole-slide images. First, we present an AI-based method to segment multiple tissue compartments in the H&E-stained whole-slide image, which provides a different, more perceptible picture of tissue morphology and composition. We test and compare a panel of state-of-the-art loss functions available for segmentation models, and provide indications about their use in histopathology image segmentation, based on the analysis of a) a multi-centric cohort of CRC cases from five medical centers in the Netherlands and Germany, and b) two publicly available datasets on segmentation in CRC. Second, we use the best performing AI model as the basis for a computer-aided diagnosis system (CAD) that classifies colon biopsies into four main categories that are relevant pathologically. We report the performance of this system on an independent cohort of more than 1,000 patients. The results show the potential of such an AI-based system to assist pathologists in diagnosis of CRC in the context of population screening. We have made the segmentation model available for research use on https://grand-challenge.org/algorithms/colon-tissue-segmentation/.
Extending super-resolution imaging techniques to objects hidden in strongly scattering media potentially revolutionize the technical analysis for much broader categories of samples, such as biological tissues. The main challenge is the medias inhomog
eneous structures which scramble the light path and create noise-like speckle patterns, hindering the objects visualization even at a low-resolution level. Here, we propose a computational method relying on the objects spatial and temporal fluctuation to visualize nanoscale objects through scattering media non-invasively. The fluctuating object can be achieved by random speckle illumination, illuminating through dynamic scattering media, or flickering emitters. The optical memory effect allows us to derive the object at diffraction limit resolution and estimate the point spreading function (PSF). Multiple images of the fluctuating object are obtained by deconvolution, then super-resolution images are achieved by computing the high order cumulants. Non-linearity of high order cumulant significantly suppresses the noise and artifacts in the resulting images and enhances the resolution by a factor of $sqrt{N}$, where $N$ is the cumulant order. Our non-invasive super-resolution speckle fluctuation imaging (NISFFI) presents a nanoscopy technique with very simple hardware to visualize samples behind scattering media.
Non-line-of-sight (NLOS) imaging is based on capturing the multi-bounce indirect reflections from the hidden objects. Active NLOS imaging systems rely on the capture of the time of flight of light through the scene, and have shown great promise for t
he accurate and robust reconstruction of hidden scenes without the need for specialized scene setups and prior assumptions. Despite that existing methods can reconstruct 3D geometries of the hidden scene with excellent depth resolution, accurately recovering object textures and appearance with high lateral resolution remains an challenging problem. In this work, we propose a new problem formulation, called NLOS photography, to specifically address this deficiency. Rather than performing an intermediate estimate of the 3D scene geometry, our method follows a data-driven approach and directly reconstructs 2D images of a NLOS scene that closely resemble the pictures taken with a conventional camera from the location of the relay wall. This formulation largely simplifies the challenging reconstruction problem by bypassing the explicit modeling of 3D geometry, and enables the learning of a deep model with a relatively small training dataset. The results are NLOS reconstructions of unprecedented lateral resolution and image quality.
Nasopharyngeal Carcinoma (NPC) is a worldwide malignant epithelial cancer. Survival prediction is a major concern for NPC patients, as it provides early prognostic information that is needed to guide treatments. Recently, deep learning, which leverag
es Deep Neural Networks (DNNs) to learn deep representations of image patterns, has been introduced to the survival prediction in various cancers including NPC. It has been reported that image-derived end-to-end deep survival models have the potential to outperform clinical prognostic indicators and traditional radiomics-based survival models in prognostic performance. However, deep survival models, especially 3D models, require large image training data to avoid overfitting. Unfortunately, medical image data is usually scarce, especially for Positron Emission Tomography/Computed Tomography (PET/CT) due to the high cost of PET/CT scanning. Compared to Magnetic Resonance Imaging (MRI) or Computed Tomography (CT) providing only anatomical information of tumors, PET/CT that provides both anatomical (from CT) and metabolic (from PET) information is promising to achieve more accurate survival prediction. However, we have not identified any 3D end-to-end deep survival model that applies to small PET/CT data of NPC patients. In this study, we introduced the concept of multi-task leaning into deep survival models to address the overfitting problem resulted from small data. Tumor segmentation was incorporated as an auxiliary task to enhance the models efficiency of learning from scarce PET/CT data. Based on this idea, we proposed a 3D end-to-end Deep Multi-Task Survival model (DeepMTS) for joint survival prediction and tumor segmentation. Our DeepMTS can jointly learn survival prediction and tumor segmentation using PET/CT data of only 170 patients with advanced NPC.
Medical image segmentation has significantly benefitted thanks to deep learning architectures. Furthermore, semi-supervised learning (SSL) has recently been a growing trend for improving a models overall performance by leveraging abundant unlabeled d
ata. Moreover, learning multiple tasks within the same model further improves model generalizability. To generate smoother and accurate segmentation masks from 3D cardiac MR images, we present a Multi-task Cross-task learning consistency approach to enforce the correlation between the pixel-level (segmentation) and the geometric-level (distance map) tasks. Our extensive experimentation with varied quantities of labeled data in the training sets justifies the effectiveness of our model for the segmentation of the left atrial cavity from Gadolinium-enhanced magnetic resonance (GE-MR) images. With the incorporation of uncertainty estimates to detect failures in the segmentation masks generated by CNNs, our study further showcases the potential of our model to flag low-quality segmentation from a given model.
