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Register a new userDETECTION OF miRNA USING SURFACE PLASMON RESONANCE (SPR)
الكشف عن miRNA باستخدام SPR
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Aِl-Baath University ورقة بحثية
Publication date
2016
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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تعد MicroRNAs جهة وحيدة غير مشفرة لجزيئات ال RNA القادرة على تنظيم ترجمة البروتين الهدف و بالتالي التحكم بالوظائف البيولوجية, تعتبر miRANs مؤهلة لتكون علامات تشخيصية قادرة على المساعدة في الفحص المبكر عن الأمراض, ففي حالة مرض ما تكون تراكيز ال miRNAs المحددة و المخصصة لهذا المرض متفاوتة الكمية. للكشف عن miRNA نستخدم تقنية ال SPR (جهاز استشعار سطح الرنين البلازمي) و التي تسمح بقياس التفاعلات بين الجزيئات على سطح ما بشكل آني. لهذا الغرض, تثبت عينات ال thiolated LNA على السطح الذهبي للشريحة.
MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules, which can regulate the translation of target proteins and thereby control biological functions. They qualify as diagnostic markers and can help to detect diseases earlier. In case of a disease the concentrations of specific miRNAs which are characteristic for it do vary in quantity. For the detection of miRNA we are using a surface plasmon resonance (SPR) biosensor, which allows to measure interactions of molecules at an interface in real-time. For this, thiolated LNA capture probes are immobilized on the gold chip.
References used
Nguyen, H.H., Park, J., Kang, S., Kim, M., 2015- Surface plasmon resonance: a versatile technique for biosensor applications. Sensors (Basel, Switzerland).15, pp.10481– 10510
Mariani, S., Minunni, M., 2014- Surface plasmon resonance applications in clinical analysis. Analytical and bioanalytical chemistry. 406, pp. 2303–2323
Šípová, H., Homola, J., 2013- Surface plasmon resonance sensing of nucleic acids: a review. AnalyticaChimicaActa. 773, pp. 9–23
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