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Chemical Synovectomy with Rifmpicin Injections in the Knee in Hemophilic Patients

الاستئصال الكيماوي للغشاء الزليل بحقن الريفامبيسين عند مرضى الناعور في مفصل الركبة

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 Publication date 2009
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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Background: Many options are available for the treatment of synovitis or target joint in hemophilia to prevent recurrent bleeding and further joint destruction when conservative therapy fails such as chemical synovectomy. Chemical synovectomy with Rifampicin has been used for many years in several clinical trials with good results and without serious complications. Objective :evaluate the safety and the efficacy of this procedure in the Syrian hemophilic patients. Conclusion: chemical synovectomy with rifampicin is a good treatment, cheap and safe in hemophilic patients.


Artificial intelligence review:
Research summary
تتناول هذه الدراسة فعالية وأمان استئصال الغشاء الزليلي الكيميائي باستخدام حقن الريفامبيسين لدى مرضى الناعور في مفصل الركبة. الناعور هو اضطراب نزفي شائع يسبب نزيفًا متكررًا في المفاصل، مما يؤدي إلى إعاقات حركية. تم حقن 31 مريضًا ذكورًا مصابين بالناعور (27 بالناعور A و4 بالناعور B) بمتوسط عمر 14 سنة. تم حقن الريفامبيسين أسبوعيًا لمدة خمسة أسابيع، وتم متابعة المرضى لمدة تصل إلى 12 شهرًا. أظهرت النتائج تحسنًا ملحوظًا في درجة الألم، حركة المفصل، وقطر الركبة، دون حدوث مضاعفات خطيرة. استنتجت الدراسة أن هذا الإجراء فعال وآمن وغير مكلف لعلاج التهاب الغشاء الزليلي المزمن والمفاصل الهدفية لدى مرضى الناعور.
Critical review
دراسة نقدية: الدراسة تقدم نتائج مشجعة حول فعالية وأمان استئصال الغشاء الزليلي الكيميائي باستخدام الريفامبيسين، ولكن هناك بعض النقاط التي يمكن تحسينها. أولاً، العينة المدروسة صغيرة نسبيًا مما قد يؤثر على تعميم النتائج. ثانيًا، لم يتم مقارنة النتائج مع مجموعة ضابطة مما يجعل من الصعب تقييم الفعالية بشكل دقيق. ثالثًا، تمت متابعة المرضى لمدة تصل إلى 12 شهرًا فقط، ومن المهم متابعة المرضى لفترة أطول لتقييم الفعالية والأمان على المدى البعيد. أخيرًا، لم يتم دراسة العلاقة بين عدد مرات الحقن والتحسن بشكل مفصل، مما قد يكون مفيدًا لفهم أفضل للعلاج.
Questions related to the research
  1. ما هو الهدف الرئيسي من الدراسة؟

    الهدف الرئيسي من الدراسة هو تقييم فعالية وأمان استئصال الغشاء الزليلي الكيميائي باستخدام حقن الريفامبيسين لدى مرضى الناعور في مفصل الركبة.

  2. ما هي المعايير المستخدمة لتقييم فعالية العلاج؟

    تم تقييم فعالية العلاج باستخدام عدة معايير منها درجة الألم، حركة المفصل، قطر الركبة، وتصنيفات سريرية وشعاعية مختلفة مثل تصنيف آرنولد وتصنيف بالتيستيلا.

  3. ما هي النتائج الرئيسية التي توصلت إليها الدراسة؟

    أظهرت الدراسة تحسنًا ملحوظًا في درجة الألم، حركة المفصل، وقطر الركبة لدى المرضى، دون حدوث مضاعفات خطيرة، مما يشير إلى فعالية وأمان العلاج.

  4. ما هي التوصيات المستقبلية التي قدمتها الدراسة؟

    أوصت الدراسة بمتابعة المرضى لفترات زمنية أطول لتقييم الفعالية والأمان على المدى البعيد، ودراسة العلاقة بين عدد مرات الحقن والتحسن بشكل مفصل، بالإضافة إلى مقارنة النتائج مع مجموعة ضابطة.


References used
Mannucci, PM, Tuddenham, EG. The hemophilias--from royal genes to gene therapy. N Engl J Med 2001; 344:1773
Rosendaal, F, Aledort, LM, et al. Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis. Factor VII and Factor IX Subcommittee. Thromb Haemost 2001; 85:560
Nienhuis, AW. Development of gene therapy for blood disorders. Blood 2008; 111:4431
Shetty, S, Vora, S, Kulkarni, B, et al. Contribution of natural anticoagulant and fibrinolytic factors in modulating the clinical severity of haemophilia patients. Br J Haematol 2007; 138:541
Van Dijk, K, Van Der, Bom JG, Fischer, K, et al. Do prothrombotic factors influence clinical phenotype of severe haemophilia? A review of the literature. Thromb Haemost 2004; 92:305
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