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How do some Bayesian Network machine learned graphs compare to causal knowledge?

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 Publication date 2021
and research's language is English




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The graph of a Bayesian Network (BN) can be machine learned, determined by causal knowledge, or a combination of both. In disciplines like bioinformatics, applying BN structure learning algorithms can reveal new insights that would otherwise remain unknown. However, these algorithms are less effective when the input data are limited in terms of sample size, which is often the case when working with real data. This paper focuses on purely machine learned and purely knowledge-based BNs and investigates their differences in terms of graphical structure and how well the implied statistical models explain the data. The tests are based on four previous case studies whose BN structure was determined by domain knowledge. Using various metrics, we compare the knowledge-based graphs to the machine learned graphs generated from various algorithms implemented in TETRAD spanning all three classes of learning. The results show that, while the algorithms produce graphs with much higher model selection score, the knowledge-based graphs are more accurate predictors of variables of interest. Maximising score fitting is ineffective in the presence of limited sample size because the fitting becomes increasingly distorted with limited data, guiding algorithms towards graphical patterns that share higher fitting scores and yet deviate considerably from the true graph. This highlights the value of causal knowledge in these cases, as well as the need for more appropriate fitting scores suitable for limited data. Lastly, the experiments also provide new evidence that support the notion that results from simulated data tell us little about actual real-world performance.



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Bayesian Networks (BNs) have become a powerful technology for reasoning under uncertainty, particularly in areas that require causal assumptions that enable us to simulate the effect of intervention. The graphical structure of these models can be determined by causal knowledge, learnt from data, or a combination of both. While it seems plausible that the best approach in constructing a causal graph involves combining knowledge with machine learning, this approach remains underused in practice. We implement and evaluate 10 knowledge approaches with application to different case studies and BN structure learning algorithms available in the open-source Bayesys structure learning system. The approaches enable us to specify pre-existing knowledge that can be obtained from heterogeneous sources, to constrain or guide structure learning. Each approach is assessed in terms of structure learning effectiveness and efficiency, including graphical accuracy, model fitting, complexity, and runtime; making this the first paper that provides a comparative evaluation of a wide range of knowledge approaches for BN structure learning. Because the value of knowledge depends on what data are available, we illustrate the results both with limited and big data. While the overall results show that knowledge becomes less important with big data due to higher learning accuracy rendering knowledge less important, some of the knowledge approaches are actually found to be more important with big data. Amongst the main conclusions is the observation that reduced search space obtained from knowledge does not always imply reduced computational complexity, perhaps because the relationships implied by the data and knowledge are in tension.
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