Do you want to publish a course? Click here

Multilayer Network Analysis of the Drug Pipeline in the Global Pharmaceutical Industry

70   0   0.0 ( 0 )
 Added by Hiromitsu Goto
 Publication date 2020
  fields Physics Financial
and research's language is English




Ask ChatGPT about the research

Generally, open innovation is a lucrative research topic within industries relying on innovation, such as the pharmaceutical industry, which are also known as knowledge-intensive industries. However, the dynamics of drug pipelines within a small-medium enterprise level in the global economy remains concerning. To reveal the actual situation of pharmaceutical innovation, we investigate the feature of knowledge flows between the licensor and licensee in the drug pipeline based on a multilayer network constructed with the drug pipeline, global supply chain, and ownership data. Thus, our results demonstrate proven similarities between the knowledge flows in the drug pipeline among the supply chains, which generally agrees with the situation of pharmaceutical innovation collaborated with other industries, such as the artificial intelligence industry.



rate research

Read More

This paper studies the structure of the Japanese production network, which includes one million firms and five million supplier-customer links. This study finds that this network forms a tightly-knit structure with a core giant strongly connected component (GSCC) surrounded by IN and OUT components constituting two half-shells of the GSCC, which we call atextit{walnut} structure because of its shape. The hierarchical structure of the communities is studied by the Infomap method, and most of the irreducible communities are found to be at the second level. The composition of some of the major communities, including overexpressions regarding their industrial or regional nature, and the connections that exist between the communities are studied in detail. The findings obtained here cause us to question the validity and accuracy of using the conventional input-output analysis, which is expected to be useful when firms in the same sectors are highly connected to each other.
114 - Kyu-Min Lee , Kwang-Il Goh 2016
Many real-world complex systems across natural, social, and economical domains consist of manifold layers to form multiplex networks. The multiple network layers give rise to nonlinear effect for the emergent dynamics of systems. Especially, weak layers that can potentially play significant role in amplifying the vulnerability of multiplex networks might be shadowed in the aggregated single-layer network framework which indiscriminately accumulates all layers. Here we present a simple model of cascading failure on multiplex networks of weight-heterogeneous layers. By simulating the model on the multiplex network of international trades, we found that the multiplex model produces more catastrophic cascading failures which are the result of emergent collective effect of coupling layers, rather than the simple sum thereof. Therefore risks can be systematically underestimated in single-layer network analyses because the impact of weak layers can be overlooked. We anticipate that our simple theoretical study can contribute to further investigation and design of optimal risk-averse real-world complex systems.
In this paper we analyse the bipartite Colombian firms-products network, throughout a period of five years, from 2010 to 2014. Our analysis depicts a strongly modular system, with several groups of firms specializing in the export of specific categories of products. These clusters have been detected by running the bipartite variant of the traditional modularity maximization, revealing a bi-modular structure. Interestingly, this finding is refined by applying a recently-proposed algorithm for projecting bipartite networks on the layer of interest and, then, running the Louvain algorithm on the resulting monopartite representations. Important structural differences emerge upon comparing the Colombian firms-products network with the World Trade Web, in particular, the bipartite representation of the latter is not characterized by a similar block-structure, as the modularity maximization fails in revealing (bipartite) nodes clusters. This points out that economic systems behave differently at different scales: while countries tend to diversify their production --potentially exporting a large number of different products-- firms specialize in exporting (substantially very limited) baskets of basically homogeneous products.
Urban scaling analysis, the study of how aggregated urban features vary with the population of an urban area, provides a promising framework for discovering commonalities across cities and uncovering dynamics shared by cities across time and space. Here, we use the urban scaling framework to study an important, but under-explored feature in this community - income inequality. We propose a new method to study the scaling of income distributions by analyzing total income scaling in population percentiles. We show that income in the least wealthy decile (10%) scales close to linearly with city population, while income in the most wealthy decile scale with a significantly superlinear exponent. In contrast to the superlinear scaling of total income with city population, this decile scaling illustrates that the benefits of larger cities are increasingly unequally distributed. For the poorest income deciles, cities have no positive effect over the null expectation of a linear increase. We repeat our analysis after adjusting income by housing cost, and find similar results. We then further analyze the shapes of income distributions. First, we find that mean, variance, skewness, and kurtosis of income distributions all increase with city size. Second, the Kullback-Leibler divergence between a citys income distribution and that of the largest city decreases with city population, suggesting the overall shape of income distribution shifts with city population. As most urban scaling theories consider densifying interactions within cities as the fundamental process leading to the superlinear increase of many features, our results suggest this effect is only seen in the upper deciles of the cities. Our finding encourages future work to consider heterogeneous models of interactions to form a more coherent understanding of urban scaling.
A multilayer network approach combines different network layers, which are connected by interlayer edges, to create a single mathematical object. These networks can contain a variety of information types and represent different aspects of a system. However, the process for selecting which information to include is not always straightforward. Using data on two agonistic behaviors in a captive population of monk parakeets (Myiopsitta monachus), we developed a framework for investigating how pooling or splitting behaviors at the scale of dyadic relationships (between two individuals) affects individual- and group-level social properties. We designed two reference models to test whether randomizing the number of interactions across behavior types results in similar structural patterns as the observed data. Although the behaviors were correlated, the first reference model suggests that the two behaviors convey different information about some social properties and should therefore not be pooled. However, once we controlled for data sparsity, we found that the observed measures corresponded with those from the second reference model. Hence, our initial result may have been due to the unequal frequencies of each behavior. Overall, our findings support pooling the two behaviors. Awareness of how selected measurements can be affected by data properties is warranted, but nonetheless our framework disentangles these efforts and as a result can be used for myriad types of behaviors and questions. This framework will help researchers make informed and data-driven decisions about which behaviors to pool or separate, prior to using the data in subsequent multilayer network analyses.
comments
Fetching comments Fetching comments
Sign in to be able to follow your search criteria
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا