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Register a new userToward Efficient Breast Cancer Diagnosis and Survival Prediction Using L-Perceptron
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Added by
Hadi Mansourifar
Publication date
2018
fields
Informatics Engineering
and research's language is
English
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Breast cancer is the most frequently reported cancer type among the women around the globe and beyond that it has the second highest female fatality rate among all cancer types. Despite all the progresses made in prevention and early intervention, early prognosis and survival prediction rates are still unsatisfactory. In this paper, we propose a novel type of perceptron called L-Perceptron which outperforms all the previous supervised learning methods by reaching 97.42 % and 98.73 % in terms of accuracy and sensitivity, respectively in Wisconsin Breast Cancer dataset. Experimental results on Habermans Breast Cancer Survival dataset, show the superiority of proposed method by reaching 75.18 % and 83.86 % in terms of accuracy and F1 score, respectively. The results are the best reported ones obtained in 10-fold cross validation in absence of any preprocessing or feature selection.
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This report assesses different machine learning approaches to 10-year survival prediction of breast cancer patients.
Breast cancer is one of the leading fatal disease worldwide with high risk control if early discovered. Conventional method for breast screening is x-ray mammography, which is known to be challenging for early detection of cancer lesions. The dense breast structure produced due to the compression process during imaging lead to difficulties to recognize small size abnormalities. Also, inter- and intra-variations of breast tissues lead to significant difficulties to achieve high diagnosis accuracy using hand-crafted features. Deep learning is an emerging machine learning technology that requires a relatively high computation power. Yet, it proved to be very effective in several difficult tasks that requires decision making at the level of human intelligence. In this paper, we develop a new network architecture inspired by the U-net structure that can be used for effective and early detection of breast cancer. Results indicate a high rate of sensitivity and specificity that indicate potential usefulness of the proposed approach in clinical use.
Breast cancer is one of the most common cancers in women worldwide, and early detection can significantly reduce the mortality rate of breast cancer. It is crucial to take multi-scale information of tissue structure into account in the detection of breast cancer. And thus, it is the key to design an accurate computer-aided detection (CAD) system to capture multi-scale contextual features in a cancerous tissue. In this work, we present a novel graph convolutional neural network for histopathological image classification of breast cancer. The new method, named multi-scale graph wavelet neural network (MS-GWNN), leverages the localization property of spectral graph wavelet to perform multi-scale analysis. By aggregating features at different scales, MS-GWNN can encode the multi-scale contextual interactions in the whole pathological slide. Experimental results on two public datasets demonstrate the superiority of the proposed method. Moreover, through ablation studies, we find that multi-scale analysis has a significant impact on the accuracy of cancer diagnosis.
Behavior prediction plays an essential role in both autonomous driving systems and Advanced Driver Assistance Systems (ADAS), since it enhances vehicles awareness of the imminent hazards in the surrounding environment. Many existing lane change prediction models take as input lateral or angle information and make short-term (< 5 seconds) maneuver predictions. In this study, we propose a longer-term (5~10 seconds) prediction model without any lateral or angle information. Three prediction models are introduced, including a logistic regression model, a multilayer perceptron (MLP) model, and a recurrent neural network (RNN) model, and their performances are compared by using the real-world NGSIM dataset. To properly label the trajectory data, this study proposes a new time-window labeling scheme by adding a time gap between positive and negative samples. Two approaches are also proposed to address the unstable prediction issue, where the aggressive approach propagates each positive prediction for certain seconds, while the conservative approach adopts a roll-window average to smooth the prediction. Evaluation results show that the developed prediction model is able to capture 75% of real lane change maneuvers with an average advanced prediction time of 8.05 seconds.
Deriving interpretable prognostic features from deep-learning-based prognostic histopathology models remains a challenge. In this study, we developed a deep learning system (DLS) for predicting disease specific survival for stage II and III colorectal cancer using 3,652 cases (27,300 slides). When evaluated on two validation datasets containing 1,239 cases (9,340 slides) and 738 cases (7,140 slides) respectively, the DLS achieved a 5-year disease-specific survival AUC of 0.70 (95%CI 0.66-0.73) and 0.69 (95%CI 0.64-0.72), and added significant predictive value to a set of 9 clinicopathologic features. To interpret the DLS, we explored the ability of different human-interpretable features to explain the variance in DLS scores. We observed that clinicopathologic features such as T-category, N-category, and grade explained a small fraction of the variance in DLS scores (R2=18% in both validation sets). Next, we generated human-interpretable histologic features by clustering embeddings from a deep-learning based image-similarity model and showed that they explain the majority of the variance (R2 of 73% to 80%). Furthermore, the clustering-derived feature most strongly associated with high DLS scores was also highly prognostic in isolation. With a distinct visual appearance (poorly differentiated tumor cell clusters adjacent to adipose tissue), this feature was identified by annotators with 87.0-95.5% accuracy. Our approach can be used to explain predictions from a prognostic deep learning model and uncover potentially-novel prognostic features that can be reliably identified by people for future validation studies.
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