The Importance of Minimum Alveolar Concentration MAC in Controlling Anesthesia and Protection from Awareness during Surgery

This study was carried out in the Department of Anesthesia and Reanimation at AL-Assad University Hospital Lattakia Syria during the year 2012-2013 the study included 200 patients between 12 and 65 years old the most common surgical procedures they had were general surgery, urinary surgery, orthopedic surgery, genecology surgery. Patients were divided into two groups: for the first group: Propofol was used for induction and an inhaling gas with a suitable minimum alveolar concentration MAC was used for maintenance the gas used was Sevoflurane. For the second group: Thiopental or Propofol was used for induction and Sevoflurane for maintenance with MAC less than the suitable concentration. The aim of the study was to show the importance of Minimum Alveolar Concentration and keep a deep anesthesia in order to prevent awareness and recall. The result was better in the first group because the percentage of awareness and recall was less than in the second group. The study shows that the use of inhaling anesthesia is well, but the Minimum Alveolar Concentration MAC (Sevoflurane is the studied gas) must be controlled.

Anesthesia with Sevoflurane protect the myocardium in Coronary Artery Bypass Graft

Protection against cardiac ischemia/reperfusion injury is the basic objective in open heart surgery, and it may be achieved by pharmacological preconditioning or Postconditioning. In this study, we aimed to compare the effects of two different anesthetic techniques (inhalation and total intravenous anesthesia) on ischemia-reperfusion injury in Coronary Artery Bypass Graft surgery. 80 CABG patients were randomly assigned into one of tow groups: Group A Sevoflurane (n=40) and Group B total intravenous anesthesia (n=40) with Propofol . data of hemodynamic monitoring and inotrops using were recorded. Arterial blood samples were taken in the preoperative period (T0), 12th hours (T1) ,24th hours (T2) and 48th hours postoperatively, and Troponine I levels were measured . The time of ventilation, ICU and total hospitalization were recorded . Postoperative levels of troponine I were significantly lower in the Sevoflurane group with less using of inotrops and less staying in the ICU post-op . We conclude that the use of a volatile anesthetic regimen in CABG surgery associate with better preservation of myocardial function and a reduced postoperative release of troponine I.