The aim of the present research is to determine the appropriate diagnostic
methods to find out the affected fetuses with Down Syndrome in order to
decrease as possible subjecting the pregnant women to invasive prenatal
diagnosis .
This is a Prosp
ective – practical study, where /1137/ pregnant women at 13-
16 gestation weeks, ( age range: 20-42 years) were included.
Biochemical screening of the pregnant women, ultrasound screening of the
fetuses: nuchal translucency, nasal bone, which helped us to isolate the highrisk
pregnancies for Down syndrome (the potential rate of incidence ≥
0.4%).
The screen positive group included 57 pregnant ( 5.01% ) . Amniocentesis
and subsequently karyotyping was done to each woman in this group . We
found out 4 affected fetuses from 5 ( 80%) , because the following up of the
remaining pregnancies revealed a fifth affected newborn with Down
syndrome.
The early prenatal diagnosis of Down syndrome was possible in ( 80% ) by
subjecting only ( 5.01% ) of pregnants to the invasive prenatal diagnosis .
متلازمة داون
التشخيص غير الغازي قبل الولادة
المسح الكيميائي – الحيوي
المسح بالأمواج فوق الصوتية
التشخيص الغازي قبل الولادة
بزل السائل الأمنيوسي
تحديد الصيغة الصبغية
Down syndrome
Invasive prenatal diagnosis
Non invasive prenatal diagnosis
Ultrasound screening
Biochemical screening
Amniocentesis
Karyotyping
المزيد..