MicroRNAs (miRNAs) are single-stranded, non-coding RNA
molecules, which can regulate the translation of target proteins and
thereby control biological functions. They qualify as diagnostic
markers and can help to detect diseases earlier. In case o
f a disease
the concentrations of specific miRNAs which are characteristic for
it do vary in quantity. For the detection of miRNA we are using a
surface plasmon resonance (SPR) biosensor, which allows to
measure interactions of molecules at an interface in real-time. For
this, thiolated LNA capture probes are immobilized on the gold
chip.
