Asthma exacerbations can be frequent and range in severity from relatively mild to
status asthmaticus. While the efficacy of intravenous MgSO4 hasbeen demonstrated, the
informations available on its inhaled role still low and conflicting, so the st
udy aim to
investigate the effect of thecombinationof MgSO4and salbutamol in the management of
acute asthma attack.
A randomized clinical trial was conducted on 76 patients, divided into two groups:
experimental (40) and control (36) patients. The trial received nebulised salbutamol with
magnesium sulphate and control nebulised salbutamol with saline serum 0.9% on three
sessions in 20 minutes. Signs of respiratory distress, wheezing, respiratory rate, pulse,
Sao2 and PEF were assessed.
Magnesium sulphate showed a significant effect in improving respiratory rate, Sao2
and PEF starting from the 20th minute( P <0.05), but did not observe the effect of MgSO4
in improving signs of respiratory distress, pulse and wheezing(P> 0,05), no side effects
attributed to magnesium sulphate were observed.Inhaled MgSO4, incombination with
salbutamol, appears to have benefits in the treatment of acute asthma attack.
