Preparation of prolonged release matrix tablets of verapamil and comparaison with coated ones

The purpose of this study was to prepare prolonged release tablets of verapamil: matrix and coated tablets, because of the importance of these systems in drug delivery and improving the patient compliance and therapeutic efficacy .Different formulations were prepared by using different release-modifiers polymers (EURL100 and EURS100). Direct compression technique was used to prepare coated tablets while matrix tablets were prepared by wet granulation and direct compression methods. The prepared formulations were evaluated in terms of their precompression parameters, physical characteristics, dissolution test and in vitro drug release kinetic studies. The results showed that matrix tablets containing 7.5or10% of EuRS100 and EuRL100 respectively and that coated tablets prepared by using coating solution (15%) which was applied about 120(in case of EuRS100) or 280 (in case of EuRL100) times were the best. These tablets released about 90-95% of verapamil within 24h

A new Spectrophotometric Method for the Determination of Lisinopril in Bulk and Tablets after Derivatization with 4- Nitrobenzene Diazonium Tetra Fluoro Borate

A new colorimetric analytical method was developed for determination of Lisinopril in bulk and tablets . The method is depended on derivatization chemical reaction between Lisinopril and 4- nitrobenzene diazonium tetra fluoro borate in non aqueous medium to give color derivatives with max. absorption at 293.8 nm . The resulting color was measured spectrophotometrically . The absorbance concentration plots were recti linear over the range 5-50 μg /ml. The method applied for determination the Lisinopril in Tablet, The percentage recoveries was 98% ± 2.4. The results obtained were in accordance with those found using the HPLC standard method in Pharmacopoeia .