Investigation The Expression of Chemokine Receptor CXCR4 in Head and Neck Squamous Cell Carcinoma-metastiatic lymph Nodes and Compare It with its Primary Tumor (clinical immunohistochemistry study)

this study Aimes to Investigate CXCR4 expression in primary head and neck squamous cell carcinomas tumors in all clinical stages and histological grades, then compare it with control normal oral epithelial tissues. Compare metastatic lymph nodes CXCR4 expression with their primary HNSCC tumors at high stages which associated with metastatic lymph nodes.

Investigating the pathway of protein p53 inhibition in head and neck squamous cell carcinoma (Immunohistochemistry study)

The protein p53 is the guardian of the cell gene contents from changes, and the gene that produces it is called Tumor Suppressor Gene which mutates in 50% of Squamous cell carcinoma’s cases producing defective protein .Studies have not detailed the expression ratio of the defective protein Within the cancer cells, also studies have less details about the cases which did not show a mutated protein.