Experimentally induced inflammation of the gingiva of wistar rats Shown
remarkable increase in prostaglandins E. Adminstration of endometacin drug at
the stage of acut inflammation has led to a dicrease of prostaglandins E level in
the gingiva and
the improvement of the periodontal inflammation and the general
state of the animal .
This research has proved the importance of increasing biosynthesis of
prostaglandin E (and consequently the increase of prostaglandin E in the gingiva)
in the begening and development of periodontal inflammation , in addition to the
importance using prostaglandins synthesis inhibitors in the treatment of this
disease .
