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The Oxford English Dictionary defines precision medicine as medical care designed to optimize efficiency or therapeutic benefit for particular groups of patients, especially by using genetic or molecular profiling. It is not an entirely new idea: physicians from ancient times have recognized that medical treatment needs to consider individual variations in patient characteristics. However, the modern precision medicine movement has been enabled by a confluence of events: scientific advances in fields such as genetics and pharmacology, technological advances in mobile devices and wearable sensors, and methodological advances in computing and data sciences. This chapter is about bandit algorithms: an area of data science of special relevance to precision medicine. With their roots in the seminal work of Bellman, Robbins, Lai and others, bandit algorithms have come to occupy a central place in modern data science ( Lattimore and Szepesvari, 2020). Bandit algorithms can be used in any situation where treatment decisions need to be made to optimize some health outcome. Since precision medicine focuses on the use of patient characteristics to guide treatment, contextual bandit algorithms are especially useful since they are designed to take such information into account. The role of bandit algorithms in areas of precision medicine such as mobile health and digital phenotyping has been reviewed before (Tewari and Murphy, 2017; Rabbi et al., 2019). Since these reviews were published, bandit algorithms have continued to find uses in mobile health and several new topics have emerged in the research on bandit algorithms. This chapter is written for quantitative researchers in fields such as statistics, machine learning, and operations research who might be interested in knowing more about the algorithmic and mathematical details of bandit algorithms that have been used in mobile health.
The complexity of human cancer often results in significant heterogeneity in response to treatment. Precision medicine offers potential to improve patient outcomes by leveraging this heterogeneity. Individualized treatment rules (ITRs) formalize prec
The stochastic contextual bandit problem, which models the trade-off between exploration and exploitation, has many real applications, including recommender systems, online advertising and clinical trials. As many other machine learning algorithms, c
We study a bandit version of phase retrieval where the learner chooses actions $(A_t)_{t=1}^n$ in the $d$-dimensional unit ball and the expected reward is $langle A_t, theta_starrangle^2$ where $theta_star in mathbb R^d$ is an unknown parameter vecto
We discuss in this survey several network modeling methods and their applicability to precision medicine. We review several network centrality methods (degree centrality, closeness centrality, eccentricity centrality, betweenness centrality, and eige
In this paper we propose the first multi-armed bandit algorithm based on re-sampling that achieves asymptotically optimal regret simultaneously for different families of arms (namely Bernoulli, Gaussian and Poisson distributions). Unlike Thompson Sam