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Background SAMtools and BCFtools are widely used programs for processing and analysing high-throughput sequencing data. Findings The first version appeared online twelve years ago and has been maintained and further developed ever since, with many new features and improvements added over the years. The SAMtools and BCFtools packages represent a unique collection of tools that have been used in numerous other software projects and countless genomic pipelines. Conclusion Both SAMtools and BCFtools are freely available on GitHub under the permissive MIT licence, free for both non-commercial and commercial use. Both packages have been installed over a million times via Bioconda. The source code and documentation are available from http://www.htslib.org.
The Galaxy Zoo (GZ) project has provided quantitative visual morphologies for over a million galaxies, and has been part of a reinvigoration of interest in the morphologies of galaxies and what they reveal about galaxy evolution. Morphological inform
We discuss the origin of the optical variations in the Narrow line Seyfert 1 galaxy NGC 4051 and present the results of a cross-correlation study using X-ray and optical light curves spanning more than 12 years. The emission is highly variable in all
The availability of genomic data is often essential to progress in biomedical research, personalized medicine, drug development, etc. However, its extreme sensitivity makes it problematic, if not outright impossible, to publish or share it. As a resu
Much evolutionary information is stored in the fluctuations of protein length distributions. The genome size and non-coding DNA content can be calculated based only on the protein length distributions. So there is intrinsic relationship between the c
We investigate the consequences of adopting the criteria used by the state of California, as described by Myers et al. (2011), for conducting familial searches. We carried out a simulation study of randomly generated profiles of related and unrelated