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Social context plays an important role in perpetuating or reducing HIV risk behaviors. This study analyzed the network and individual attributes that were associated with the likelihood that people who inject drugs (PWID) will engage in HIV risk behaviors with one another. We analyze data collected in the Social Risk Factors and HIV Risk Study (SFHR) and Transmission Reduction Intervention Project (TRIP) to perform the analysis. Exponential random graph models were used to determine which attributes were associated with the likelihood of people engaging in HIV risk behaviors, such as injection behaviors that are associated with one another, among PWID. Results across all models and across both data sets indicated that people were more likely to engage in risk behaviors with others who were similar to them in some way (e.g., were the same sex, race/ethnicity, living conditions). In both SFHR and TRIP, we explore the effects of missingness at individual and network levels on the likelihood of individuals to engage in HIV risk behaviors among PWID. In this study, we found that known individual-level risk factors, including housing instability and race/ethnicity, are also important factors in determining the structure of the observed network among PWID. Future development of interventions should consider not only individual risk factors, but communities and social influences leaving individuals vulnerable to HIV risk.
Evaluating causal effects in the presence of interference is challenging in network-based studies of hard to reach populations. Like many such populations, people who inject drugs (PWID) are embedded in social networks and often exert influence on ot
Equipment sharing among people who inject drugs (PWID) is a key risk factor in infection by hepatitis C virus (HCV). Both the effectiveness and cost-effectiveness of interventions aimed at reducing HCV transmission in this population (such as opioid
Background: Highly effective direct-acting antiviral (DAA) regimens (90% efficacy) are becoming available for hepatitis C virus (HCV) treatment. This therapeutic revolution leads us to consider possibility of eradicating the virus. However, for this,
Access and adherence to antiretroviral therapy (ART) has transformed the face of HIV infection from a fatal to a chronic disease. However, ART is also known for its side effects. Studies have reported that ART is associated with depressive symptomato
Risks threatening modern societies form an intricately interconnected network that often underlies crisis situations. Yet, little is known about how risk materializations in distinct domains influence each other. Here we present an approach in which