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The purpose of this study is to develop a deep learning based method that can automatically generate segmentations on cone-beam CT (CBCT) for head and neck online adaptive radiation therapy (ART), where expert-drawn contours in planning CT (pCT) can serve as prior knowledge. Due to lots of artifacts and truncations on CBCT, we propose to utilize a learning based deformable image registration method and contour propagation to get updated contours on CBCT. Our method takes CBCT and pCT as inputs, and output deformation vector field and synthetic CT (sCT) at the same time by jointly training a CycleGAN model and 5-cascaded Voxelmorph model together.The CycleGAN serves to generate sCT from CBCT, while the 5-cascaded Voxelmorph serves to warp pCT to sCTs anatommy. The segmentation results were compared to Elastix, Voxelmorph and 5-cascaded Voxelmorph on 18 structures including left brachial plexus, right brachial plexus, brainstem, oral cavity, middle pharyngeal constrictor, superior pharyngeal constrictor, inferior pharyngeal constrictor, esophagus, nodal gross tumor volume, larynx, mandible, left masseter, right masseter, left parotid gland, right parotid gland, left submandibular gland, right submandibular gland, and spinal cord. Results show that our proposed method can achieve average Dice similarity coefficients and 95% Hausdorff distance of 0.83 and 2.01mm. As compared to other methods, our method has shown better accuracy to Voxelmorph and 5-cascaded Voxelmorph, and comparable accuracy to Elastix but much higher efficiency. The proposed method can rapidly and simultaneously generate sCT with correct CT numbers and propagate contours from pCT to CBCT for online ART re-planning.
Adaptive radiotherapy (ART), especially online ART, effectively accounts for positioning errors and anatomical changes. One key component of online ART is accurately and efficiently delineating organs at risk (OARs) and targets on online images, such
Purpose: Organ-at-risk (OAR) delineation is a key step for cone-beam CT (CBCT) based adaptive radiotherapy planning that can be a time-consuming, labor-intensive, and subject-to-variability process. We aim to develop a fully automated approach aided
In adaptive radiotherapy, deformable image registration is often conducted between the planning CT and treatment CT (or cone beam CT) to generate a deformation vector field (DVF) for dose accumulation and contour propagation. The auto propagated cont
Computed tomography (CT) to cone-beam computed tomography (CBCT) deformable image registration (DIR) is a crucial step in adaptive radiation therapy. Current intensity-based registration algorithms, such as demons, may fail in the context of CT-CBCT
Purpose: Dual-energy CT (DECT) has been used to derive relative stopping power (RSP) map by obtaining the energy dependence of photon interactions. The DECT-derived RSP maps could potentially be compromised by image noise levels and the severity of a