ترغب بنشر مسار تعليمي؟ اضغط هنا

Torus Principal Component Analysis with an Application to RNA Structures

181   0   0.0 ( 0 )
 نشر من قبل Benjamin Eltzner
 تاريخ النشر 2015
والبحث باللغة English




اسأل ChatGPT حول البحث

There are several cutting edge applications needing PCA methods for data on tori and we propose a novel torus-PCA method with important properties that can be generally applied. There are two existing general methods: tangent space PCA and geodesic PCA. However, unlike tangent space PCA, our torus-PCA honors the cyclic topology of the data space whereas, unlike geodesic PCA, our torus-PCA produces a variety of non-winding, non-dense descriptors. This is achieved by deforming tori into spheres and then using a variant of the recently developed principle nested spheres analysis. This PCA analysis involves a step of small sphere fitting and we provide an improved test to avoid overfitting. However, deforming tori into spheres creates singularities. We introduce a data-adaptive pre-clustering technique to keep the singularities away from the data. For the frequently encountered case that the residual variance around the PCA main component is small, we use a post-mode hunting technique for more fine-grained clustering. Thus in general, there are three successive interrelated key steps of torus-PCA in practice: pre-clustering, deformation, and post-mode hunting. We illustrate our method with two recently studied RNA structure (tori) data sets: one is a small RNA data set which is established as the benchmark for PCA and we validate our method through this data. Another is a large RNA data set (containing the small RNA data set) for which we show that our method provides interpretable principal components as well as giving further insight into its structure.



قيم البحث

اقرأ أيضاً

230 - H. Robert Frost 2020
We present a novel technique for sparse principal component analysis. This method, named Eigenvectors from Eigenvalues Sparse Principal Component Analysis (EESPCA), is based on the recently detailed formula for computing normed, squared eigenvector l oadings of a Hermitian matrix from the eigenvalues of the full matrix and associated sub-matrices. Relative to the state-of-the-art LASSO-based sparse PCA method of Witten, Tibshirani and Hastie, the EESPCA technique offers a two-orders-of-magnitude improvement in computational speed, does not require estimation of tuning parameters, and can more accurately identify true zero principal component loadings across a range of data matrix sizes and covariance structures. Importantly, EESPCA achieves these performance benefits while maintaining a reconstruction error close to that generated by the Witten et al. approach. EESPCA is a practical and effective technique for sparse PCA with particular relevance to computationally demanding problems such as the analysis of large data matrices or statistical techniques like resampling that involve the repeated application of sparse PCA.
Principal component analysis (PCA) is an important tool in exploring data. The conventional approach to PCA leads to a solution which favours the structures with large variances. This is sensitive to outliers and could obfuscate interesting underlyin g structures. One of the equivalent definitions of PCA is that it seeks the subspaces that maximize the sum of squared pairwise distances between data projections. This definition opens up more flexibility in the analysis of principal components which is useful in enhancing PCA. In this paper we introduce scales into PCA by maximizing only the sum of pairwise distances between projections for pairs of datapoints with distances within a chosen interval of values [l,u]. The resulting principal component decompositions in Multiscale PCA depend on point (l,u) on the plane and for each point we define projectors onto principal components. Cluster analysis of these projectors reveals the structures in the data at various scales. Each structure is described by the eigenvectors at the medoid point of the cluster which represent the structure. We also use the distortion of projections as a criterion for choosing an appropriate scale especially for data with outliers. This method was tested on both artificial distribution of data and real data. For data with multiscale structures, the method was able to reveal the different structures of the data and also to reduce the effect of outliers in the principal component analysis.
126 - Tomokazu Konishi 2012
Motivation: Although principal component analysis is frequently applied to reduce the dimensionality of matrix data, the method is sensitive to noise and bias and has difficulty with comparability and interpretation. These issues are addressed by imp roving the fidelity to the study design. Principal axes and the components for variables are found through the arrangement of the training data set, and the centers of data are found according to the design. By using both the axes and the center, components for an observation that belong to various studies can be separately estimated. Both of the components for variables and observations are scaled to a unit length, which enables relationships to be seen between them. Results: Analyses in transcriptome studies showed an improvement in the separation of experimental groups and in robustness to bias and noise. Unknown samples were appropriately classified on predetermined axes. These axes well reflected the study design, and this facilitated the interpretation. Together, the introduced concepts resulted in improved generality and objectivity in the analytical results, with the ability to locate hidden structures in the data.
We consider the problem of decomposing a large covariance matrix into the sum of a low-rank matrix and a diagonally dominant matrix, and we call this problem the Diagonally-Dominant Principal Component Analysis (DD-PCA). DD-PCA is an effective tool f or designing statistical methods for strongly correlated data. We showcase the use of DD-PCA in two statistical problems: covariance matrix estimation, and global detection in multiple testing. Using the output of DD-PCA, we propose a new estimator for estimating a large covariance matrix with factor structure. Thanks to a nice property of diagonally dominant matrices, this estimator enjoys the advantage of simultaneous good estimation of the covariance matrix and the precision matrix (by a plain inversion). A plug-in of this estimator to linear discriminant analysis and portfolio optimization yields appealing performance in real data. We also propose two new tests for testing the global null hypothesis in multiple testing when the $z$-scores have a factor covariance structure. Both tests first use DD-PCA to adjust the individual $p$-values and then plug in the adjusted $p$-values to the Higher Criticism (HC) test. These new tests significantly improve over the HC test and compare favorably with other existing tests. For computation of DD-PCA, we propose an iterative projection algorithm and an ADMM algorithm.
141 - Yixuan Qiu , Jing Lei , 2019
Sparse principal component analysis (PCA) is an important technique for dimensionality reduction of high-dimensional data. However, most existing sparse PCA algorithms are based on non-convex optimization, which provide little guarantee on the global convergence. Sparse PCA algorithms based on a convex formulation, for example the Fantope projection and selection (FPS), overcome this difficulty, but are computationally expensive. In this work we study sparse PCA based on the convex FPS formulation, and propose a new algorithm that is computationally efficient and applicable to large and high-dimensional data sets. Nonasymptotic and explicit bounds are derived for both the optimization error and the statistical accuracy, which can be used for testing and inference problems. We also extend our algorithm to online learning problems, where data are obtained in a streaming fashion. The proposed algorithm is applied to high-dimensional gene expression data for the detection of functional gene groups.
التعليقات
جاري جلب التعليقات جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا