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We study in this paper certain properties of the responses of dynamical systems to external inputs. The motivation arises from molecular systems biology. and, in particular, the recent discovery of an important transient property, related to Webers law in psychophysics: fold-change detection in adapting systems, the property that scale uncertainty does not affect responses. FCD appears to play an important role in key signaling transduction mechanisms in eukaryotes, including the ERK and Wnt pathways, as well as in E.coli and possibly other prokaryotic chemotaxis pathways. In this paper, we provide further theoretical results regarding this property. Far more generally, we develop a necessary and sufficient characterization of adapting systems whose transient behaviors are invariant under the action of a set (often, a group) of symmetries in their sensory field. A particular instance is FCD, which amounts to invariance under the action of the multiplicative group of positive real numbers. Our main result is framed in terms of a notion which extends equivariant actions of compact Lie groups. Its proof relies upon control theoretic tools, and in particular the uniqueness theorem for minimal realizations.
This paper generalizes the Lasalle-Yoshizawa Theorem to switched nonsmooth systems. Filippov and Krasovskii regularizations of a switched system are shown to be contained within the convex hull of the Filippov and Krasovskii regularizations of the su
In many large systems, such as those encountered in biology or economics, the dynamics are nonlinear and are only known very coarsely. It is often the case, however, that the signs (excitation or inhibition) of individual interactions are known. This
Network reconstruction is the first step towards understanding, diagnosing and controlling the dynamics of complex networked systems. It allows us to infer properties of the interaction matrix, which characterizes how nodes in a system directly inter
The issues of robust stability for two types of uncertain fractional-order systems of order $alpha in (0,1)$ are dealt with in this paper. For the polytope-type uncertainty case, a less conservative sufficient condition of robust stability is given;
This paper proposes a fully distributed robust state-estimation (D-RBSE) method that is applicable to multi-area power systems with nonlinear measurements. We extend the recently introduced bilinear formulation of state estimation problems to a robus