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We investigate the error threshold for the emergence of quasispecies in the Eigen model. By mapping to to an effective Hamiltonian ruled by the imaginary-time Schrodinger equation, a variational ansatz is proposed and applied to calculate various quantities associated with the quasispecies. The variational ansatz gives correct predictions for the survival population of the wild-type sequence and also reveals an unexpected universal scaling behaviors near the error threshold. We check the validity of the variational ansatz by numerical methods and find excellent agreement. Though the emergence of the scaling behaviors is not yet fully understood, it is remarkable that the universal scaling function reigns even for relatively short genome length such as L=16. Further investigations may reveal the mechanism of the universal scaling and extract the essential ingredients for the emergence of the quasispecies in molecular evolution.
This paper develops a formulation of the quasispecies equations appropriate for polysomic, semiconservatively replicating genomes. This paper is an extension of previous work on the subject, which considered the case of haploid genomes. Here, we deve
The quasispecies model describes processes related to the origin of life and viral evolutionary dynamics. We discuss how the error catastrophe that reflects the transition from localized to delocalized quasispecies population is affected by catalytic
This paper develops a quasispecies model that incorporates the SOS response. We consider a unicellular, asexually replicating population of organisms, whose genomes consist of a single, double-stranded DNA molecule, i.e. one chromosome. We assume tha
Given overlapping subsets of a set of taxa (e.g. species), and posterior distributions on phylogenetic tree topologies for each of these taxon sets, how can we infer a posterior distribution on phylogenetic tree topologies for the entire taxon set? A
A variational ansatz for momentum eigenstates of translation invariant quantum spin chains is formulated. The matrix product state ansatz works directly in the thermodynamic limit and allows for an efficient implementation (cubic scaling in the bond