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The fluidic behavior of water at the micro/nano scale is studied by using of single DNA molecules as a model system. Stable curved DNA patterns with spans about one micron were generated by using of water flows, and observed by Atomic Force Microscopy. By rigorously comparing the numerical simulation results with these patterns, it is suggested that the form of the macroscopic hydrodynamic equation still works quantitatively well on the fluid flows at the nanoscale. The molecular effects, however, are still apparent that the effective viscosity of the adjacent water is considerably larger than its bulk value. Our observation is also helpful to understand of the dynamics of biomolecules in solutions from nanoscale to microscale.
The human proteome is enriched in proteins that do not fold into a stable 3D structure. These intrinsically disordered proteins (IDPs) spontaneously fluctuate between a large number of configurations in their native form. Remarkably, the disorder doe
Unicellular microscopic organisms living in aqueous environments outnumber all other creatures on Earth. A large proportion of them are able to self-propel in fluids with a vast diversity of swimming gaits and motility patterns. In this paper we pres
DNA is structurally and mechanically altered by the binding of intercalator molecules. Intercalation strongly affects the force-extension behavior of DNA, in particular the overstretching transition. We present a statistical model that captures all r
We demonstrate, through 3-dimensional discrete dislocation dynamics simulations, that the com- plex dynamical response of nano and micro crystals to external constraints can be tuned. Under load rate control, strain bursts are shown to exhibit scale-
The activity of biological cells is primarily based on chemical reactions and typically modeled as a reaction-diffusion system. Cells are, however, highly crowded with macromolecules, including a variety of molecular machines such as enzymes. The wor