اشترك بالحزمة الذهبية واحصل على وصول غير محدود شمرا أكاديميا
تسجيل مستخدم جديدApplication of Machine Learning in Early Recommendation of Cardiac Resynchronization Therapy
210
0
0.0
(
0
)
اسأل ChatGPT حول البحث
ﻻ يوجد ملخص باللغة العربية
Heart failure (HF) is a leading cause of morbidity, mortality, and health care costs. Prolonged conduction through the myocardium can occur with HF, and a device-driven approach, termed cardiac resynchronization therapy (CRT), can improve left ventricular (LV) myocardial conduction patterns. While a functional benefit of CRT has been demonstrated, a large proportion of HF patients (30-50%) receiving CRT do not show sufficient improvement. Moreover, identifying HF patients that would benefit from CRT prospectively remains a clinical challenge. Accordingly, strategies to effectively predict those HF patients that would derive a functional benefit from CRT holds great medical and socio-economic importance. Thus, we used machine learning methods of classifying HF patients, namely Cluster Analysis, Decision Trees, and Artificial neural networks, to develop predictive models of individual outcomes following CRT. Clinical, functional, and biomarker data were collected in HF patients before and following CRT. A prospective 6-month endpoint of a reduction in LV volume was defined as a CRT response. Using this approach (418 responders, 412 non-responders), each with 56 parameters, we could classify HF patients based on their response to CRT with more than 95% success. We have demonstrated that using machine learning approaches can identify HF patients with a high probability of a positive CRT response (95% accuracy), and of equal importance, identify those HF patients that would not derive a functional benefit from CRT. Developing this approach into a clinical algorithm to assist in clinical decision-making regarding the use of CRT in HF patients would potentially improve outcomes and reduce health care costs.
قيم البحث
اقرأ أيضاً
Data visualization should be accessible for all analysts with data, not just the few with technical expertise. Visualization recommender systems aim to lower the barrier to exploring basic visualizations by automatically generating results for analys
ts to search and select, rather than manually specify. Here, we demonstrate a novel machine learning-based approach to visualization recommendation that learns visualization design choices from a large corpus of datasets and associated visualizations. First, we identify five key design choices made by analysts while creating visualizations, such as selecting a visualization type and choosing to encode a column along the X- or Y-axis. We train models to predict these design choices using one million dataset-visualization pairs collected from a popular online visualization platform. Neural networks predict these design choices with high accuracy compared to baseline models. We report and interpret feature importances from one of these baseline models. To evaluate the generalizability and uncertainty of our approach, we benchmark with a crowdsourced test set, and show that the performance of our model is comparable to human performance when predicting consensus visualization type, and exceeds that of other ML-based systems.
Context: Conducting experiments is central to research machine learning research to benchmark, evaluate and compare learning algorithms. Consequently it is important we conduct reliable, trustworthy experiments. Objective: We investigate the incidenc
e of errors in a sample of machine learning experiments in the domain of software defect prediction. Our focus is simple arithmetical and statistical errors. Method: We analyse 49 papers describing 2456 individual experimental results from a previously undertaken systematic review comparing supervised and unsupervised defect prediction classifiers. We extract the confusion matrices and test for relevant constraints, e.g., the marginal probabilities must sum to one. We also check for multiple statistical significance testing errors. Results: We find that a total of 22 out of 49 papers contain demonstrable errors. Of these 7 were statistical and 16 related to confusion matrix inconsistency (one paper contained both classes of error). Conclusions: Whilst some errors may be of a relatively trivial nature, e.g., transcription errors their presence does not engender confidence. We strongly urge researchers to follow open science principles so errors can be more easily be detected and corrected, thus as a community reduce this worryingly high error rate with our computational experiments.
Predicting clinical outcome is remarkably important but challenging. Research efforts have been paid on seeking significant biomarkers associated with the therapy response or/and patient survival. However, these biomarkers are generally costly and in
vasive, and possibly dissatifactory for novel therapy. On the other hand, multi-modal, heterogeneous, unaligned temporal data is continuously generated in clinical practice. This paper aims at a unified deep learning approach to predict patient prognosis and therapy response, with easily accessible data, e.g., radiographics, laboratory and clinical information. Prior arts focus on modeling single data modality, or ignore the temporal changes. Importantly, the clinical time series is asynchronous in practice, i.e., recorded with irregular intervals. In this study, we formalize the prognosis modeling as a multi-modal asynchronous time series classification task, and propose a MIA-Prognosis framework with Measurement, Intervention and Assessment (MIA) information to predict therapy response, where a Simple Temporal Attention (SimTA) module is developed to process the asynchronous time series. Experiments on synthetic dataset validate the superiory of SimTA over standard RNN-based approaches. Furthermore, we experiment the proposed method on an in-house, retrospective dataset of real-world non-small cell lung cancer patients under anti-PD-1 immunotherapy. The proposed method achieves promising performance on predicting the immunotherapy response. Notably, our predictive model could further stratify low-risk and high-risk patients in terms of long-term survival.
In past years model-agnostic meta-learning (MAML) has been one of the most promising approaches in meta-learning. It can be applied to different kinds of problems, e.g., reinforcement learning, but also shows good results on few-shot learning tasks.
Besides their tremendous success in these tasks, it has still not been fully revealed yet, why it works so well. Recent work proposes that MAML rather reuses features than rapidly learns. In this paper, we want to inspire a deeper understanding of this question by analyzing MAMLs representation. We apply representation similarity analysis (RSA), a well-established method in neuroscience, to the few-shot learning instantiation of MAML. Although some part of our analysis supports their general results that feature reuse is predominant, we also reveal arguments against their conclusion. The similarity-increase of layers closer to the input layers arises from the learning task itself and not from the model. In addition, the representations after inner gradient steps make a broader change to the representation than the changes during meta-training.
The Right to be Forgotten is part of the recently enacted General Data Protection Regulation (GDPR) law that affects any data holder that has data on European Union residents. It gives EU residents the ability to request deletion of their personal da
ta, including training records used to train machine learning models. Unfortunately, Deep Neural Network models are vulnerable to information leaking attacks such as model inversion attacks which extract class information from a trained model and membership inference attacks which determine the presence of an example in a models training data. If a malicious party can mount an attack and learn private information that was meant to be removed, then it implies that the model owner has not properly protected their users rights and their models may not be compliant with the GDPR law. In this paper, we present two efficient methods that address this question of how a model owner or data holder may delete personal data from models in such a way that they may not be vulnerable to model inversion and membership inference attacks while maintaining model efficacy. We start by presenting a real-world threat model that shows that simply removing training data is insufficient to protect users. We follow that up with two data removal methods, namely Unlearning and Amnesiac Unlearning, that enable model owners to protect themselves against such attacks while being compliant with regulations. We provide extensive empirical analysis that show that these methods are indeed efficient, safe to apply, effectively remove learned information about sensitive data from trained models while maintaining model efficacy.
الأسئلة المقترحة
سجل دخول لتتمكن من نشر تعليقات
التعليقات
جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
