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Stimulation of target neuronal populations using optogenetic techniques during specific sleep stages has begun to elucidate the mechanisms and effects of sleep. To conduct closed-loop optogenetic sleep studies in untethered animals, we designed a fully integrated, low-power system-on-chip (SoC) for real-time sleep stage classification and stage-specific optical stimulation. The SoC consists of a 4-channel analog front-end for recording polysomnography signals, a mixed-signal machine-learning (ML) core, and a 16-channel optical stimulation back-end. A novel ML algorithm and innovative circuit design techniques improved the online classification performance while minimizing power consumption. The SoC was designed and simulated in 180 nm CMOS technology. In an evaluation using an expert labeled sleep database with 20 subjects, the SoC achieves a high sensitivity of 0.806 and a specificity of 0.947 in discriminating 5 sleep stages. Overall power consumption in continuous operation is 97 uW.
We present a high-throughput optogenetic illumination system capable of simultaneous closed-loop light delivery to specified targets in populations of moving Caenorhabditis elegans. The instrument addresses three technical challenges: it delivers tar
Sensory feedback is critical to the performance of neural prostheses that restore movement control after neurological injury. Recent advances in direct neural control of paralyzed arms present new requirements for miniaturized, low-power sensor syste
Modern network-on-chip (NoC) systems face reliability issues due to process and environmental variations. The power supply noise (PSN) in the power delivery network of a NoC plays a key role in determining reliability. PSN leads to voltage droop, whi
This paper is concerned with a bilinear control problem for enhancing convection-cooling via an incompressible velocity field. Both optimal open-loop control and closed-loop feedback control designs are addressed. First and second order optimality co
The majority of inherited retinal degenerations are due to photoreceptor cell death. In many cases ganglion cells are spared making it possible to stimulate them to restore visual function. Several studies (Bi et al., 2006; Lin et al., 2008; Sengupta