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We propose an optimal control approach in order to identify the nonlinearity in the monodomain model, from given data. This data-driven approach gives an answer to the problem of selecting the model when studying phenomena related to cardiac electrophysiology. Instead of determining coefficients of a prescribed model (like the FitzHugh-Nagumo model for instance) from empirical observations, we design the model itself, in the form of an artificial neural network. The relevance of this approach relies on the capacity approximations of neural networks. We formulate this inverse problem as an optimal control problem, and provide mathematical analysis and derivation of optimality conditions. One of the difficulties comes from the lack of smoothness of activation functions which are classically used for training neural networks. Numerical simulations demonstrate the feasibility of the strategy proposed in this work.
We consider a nonlinear reaction diffusion system of parabolic type known as the monodomain equations, which model the interaction of the electric current in a cell. Together with the FitzHugh-Nagumo model for the nonlinearity they represent defibril
In this paper we propose a new computational method for designing optimal regulators for high-dimensional nonlinear systems. The proposed approach leverages physics-informed machine learning to solve high-dimensional Hamilton-Jacobi-Bellman equations
What makes an artificial neural network easier to train and more likely to produce desirable solutions than other comparable networks? In this paper, we provide a new angle to study such issues under the setting of a fixed number of model parameters
Particle may sometimes have energy outside the range of radiation detection hardware so that the signal is saturated and useful information is lost. We have therefore investigated the possibility of using an Artificial Neural Network (ANN) to restore
The application of differential privacy to the training of deep neural networks holds the promise of allowing large-scale (decentralized) use of sensitive data while providing rigorous privacy guarantees to the individual. The predominant approach to