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The field of in-vivo neurophysiology currently uses statistical standards that are based on tradition rather than formal analysis. Typically, data from two (or few) animals are pooled for one statistical test, or a significant test in a first animal is replicated in one (or few) further animals. The use of more than one animal is widely believed to allow an inference on the population. Here, we explain that a useful inference on the population would require larger numbers and a different statistical approach. The field should consider to perform studies at that standard, potentially through coordinated multi-center efforts, for selected questions of exceptional importance. Yet, for many questions, this is ethically and/or economically not justifiable. We explain why in those studies with two (or few) animals, any useful inference is limited to the sample of investigated animals, irrespective of whether it is based on few animals, two animals or a single animal.
Experimentation and Measurement (E&M) capabilities allow organizations to accurately assess the impact of new propositions and to experiment with many variants of existing products. However, until now, the question of measuring the measurer, or valui
In the system of a gravitating Q-ball, there is a maximum charge $Q_{{rm max}}$ inevitably, while in flat spacetime there is no upper bound on $Q$ in typical models such as the Affleck-Dine model. Theoretically the charge $Q$ is a free parameter, and
We highlight that the anomalous orbits of Trans-Neptunian Objects (TNOs) and an excess in microlensing events in the 5-year OGLE dataset can be simultaneously explained by a new population of astrophysical bodies with mass several times that of Earth
Temperature, the central concept of thermal physics, is one of the most frequently employed physical quantities in common practice. Even though the operative methods of the temperature measurement are described in detail in various practical instruct
Turbulence is defined as an eddy-like state of fluid motion where the inertial-vortex forces of the eddies are larger than any other forces that tend to damp the eddies out. By this definition, turbulence always cascades from small scales (where the