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Paths $P_1,ldots,P_k$ in a graph $G=(V,E)$ are mutually induced if any two distinct $P_i$ and $P_j$ have neither common vertices nor adjacent vertices (except perhaps their end-vertices). The Induced Disjoint Paths problem is to decide if a graph $G$ with $k$ pairs of specified vertices $(s_i,t_i)$ contains $k$ mutually induced paths $P_i$ such that each $P_i$ connects $s_i$ and $t_i$. This is a classical graph problem that is NP-complete even for $k=2$. We study it for AT-free graphs. Unlike its subclasses of permutation graphs and cocomparability graphs, the class of AT-free graphs has no geometric intersection model. However, by a new, structural analysis of the behaviour of Induced Disjoint Paths for AT-free graphs, we prove that it can be solved in polynomial time for AT-free graphs even when $k$ is part of the input. This is in contrast to the situation for other well-known graph classes, such as planar graphs, claw-free graphs, or more recently, (theta,wheel)-free graphs, for which such a result only holds if $k$ is fixed. As a consequence of our main result, the problem of deciding if a given AT-free graph contains a fixed graph $H$ as an induced topological minor admits a polynomial-time algorithm. In addition, we show that such an algorithm is essentially optimal by proving that the problem is W[1]-hard with parameter $|V_H|$, even on a subclass of AT-free graph, namely cobipartite graphs. We also show that the problems $k$-in-a-Path and $k$-in-a-Tree are polynomial-time solvable on AT-free graphs even if $k$ is part of the input. These problems are to test if a graph has an induced path or induced tree, respectively, spanning $k$ given vertices.
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