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In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory networks so that the expression of target genes (partial system) is insensitive to environmental changes. Then, we found the expression levels of the remaining genes autonomously increase as a plastic response. Negative proportionality was observed between the average changes in target and remnant genes, reflecting reciprocity between the macroscopic robustness of homeostatic genes and plasticity of regulator genes. This reciprocity follows the lever principle, which was satisfied throughout the evolutionary course, imposing an evolutionary constraint.
Circadian clocks exhibit the robustness of period and plasticity of phase against environmental changes such as temperature and nutrient conditions. Thus far, however, it is unclear how both are simultaneously achieved. By investigating distinct mode
Organelles of optimum size are crucial for proper functioning of a living cell. The cell employs various mechanisms for actively sensing and controlling the size of its organelles. Recently Bauer et al have opened a new research frontier in the field
Robustness of spatial pattern against perturbations is an indispensable property of developmental processes for organisms, which need to adapt to changing environments. Although specific mechanisms for this robustness have been extensively investigat
This paper has been withdrawn. Its main conclusions have been published in On dynamics of integrate-and-fi re neural networks with conductance based synapses, arXiv:0709.4370 and http://www.frontiersin.org/computational_neuroscience/10.3389/neuro.10/002.2008/abstract
We study the surface fluctuations of a tissue with a dynamics dictated by cell-rearrangement, cell-division, and cell-death processes. Surface fluctuations are calculated in the homeostatic state, where cell division and cell death equilibrate on ave