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تسجيل مستخدم جديدPatient-independent Epileptic Seizure Prediction using Deep Learning Models
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Objective: Epilepsy is one of the most prevalent neurological diseases among humans and can lead to severe brain injuries, strokes, and brain tumors. Early detection of seizures can help to mitigate injuries, and can be used to aid the treatment of patients with epilepsy. The purpose of a seizure prediction system is to successfully identify the pre-ictal brain stage, which occurs before a seizure event. Patient-independent seizure prediction models are designed to offer accurate performance across multiple subjects within a dataset, and have been identified as a real-world solution to the seizure prediction problem. However, little attention has been given for designing such models to adapt to the high inter-subject variability in EEG data. Methods: We propose two patient-independent deep learning architectures with different learning strategies that can learn a global function utilizing data from multiple subjects. Results: Proposed models achieve state-of-the-art performance for seizure prediction on the CHB-MIT-EEG dataset, demonstrating 88.81% and 91.54% accuracy respectively. Conclusions: The Siamese model trained on the proposed learning strategy is able to learn patterns related to patient variations in data while predicting seizures. Significance: Our models show superior performance for patient-independent seizure prediction, and the same architecture can be used as a patient-specific classifier after model adaptation. We are the first study that employs model interpretation to understand classifier behavior for the task for seizure prediction, and we also show that the MFCC feature map utilized by our models contains predictive biomarkers related to interictal and pre-ictal brain states.
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Electroencephalogram (EEG) is a prominent way to measure the brain activity for studying epilepsy, thereby helping in predicting seizures. Seizure prediction is an active research area with many deep learning based approaches dominating the recent li
terature for solving this problem. But these models require a considerable number of patient-specific seizures to be recorded for extracting the preictal and interictal EEG data for training a classifier. The increase in sensitivity and specificity for seizure prediction using the machine learning models is noteworthy. However, the need for a significant number of patient-specific seizures and periodic retraining of the model because of non-stationary EEG creates difficulties for designing practical device for a patient. To mitigate this process, we propose a Siamese neural network based seizure prediction method that takes a wavelet transformed EEG tensor as an input with convolutional neural network (CNN) as the base network for detecting change-points in EEG. Compared to the solutions in the literature, which utilize days of EEG recordings, our method only needs one seizure for training which translates to less than ten minutes of preictal and interictal data while still getting comparable results to models which utilize multiple seizures for seizure prediction.
An accurate seizure prediction system enables early warnings before seizure onset of epileptic patients. It is extremely important for drug-refractory patients. Conventional seizure prediction works usually rely on features extracted from Electroence
phalography (EEG) recordings and classification algorithms such as regression or support vector machine (SVM) to locate the short time before seizure onset. However, such methods cannot achieve high-accuracy prediction due to information loss of the hand-crafted features and the limited classification ability of regression and SVM algorithms. We propose an end-to-end deep learning solution using a convolutional neural network (CNN) in this paper. One and two dimensional kernels are adopted in the early- and late-stage convolution and max-pooling layers, respectively. The proposed CNN model is evaluated on Kaggle intracranial and CHB-MIT scalp EEG datasets. Overall sensitivity, false prediction rate, and area under receiver operating characteristic curve reaches 93.5%, 0.063/h, 0.981 and 98.8%, 0.074/h, 0.988 on two datasets respectively. Comparison with state-of-the-art works indicates that the proposed model achieves exceeding prediction performance.
Epilepsy affects nearly 1% of the global population, of which two thirds can be treated by anti-epileptic drugs and a much lower percentage by surgery. Diagnostic procedures for epilepsy and monitoring are highly specialized and labour-intensive. The
accuracy of the diagnosis is also complicated by overlapping medical symptoms, varying levels of experience and inter-observer variability among clinical professions. This paper proposes a novel hybrid bilinear deep learning network with an application in the clinical procedures of epilepsy classification diagnosis, where the use of surface electroencephalogram (sEEG) and audiovisual monitoring is standard practice. Hybrid bilinear models based on two types of feature extractors, namely Convolutional Neural Networks (CNNs) and Recurrent Neural Networks (RNNs), are trained using Short-Time Fourier Transform (STFT) of one-second sEEG. In the proposed hybrid models, CNNs extract spatio-temporal patterns, while RNNs focus on the characteristics of temporal dynamics in relatively longer intervals given the same input data. Second-order features, based on interactions between these spatio-temporal features are further explored by bilinear pooling and used for epilepsy classification. Our proposed methods obtain an F1-score of 97.4% on the Temple University Hospital Seizure Corpus and 97.2% on the EPILEPSIAE dataset, comparing favourably to existing benchmarks for sEEG-based seizure type classification. The open-source implementation of this study is available at https://github.com/NeuroSyd/Epileptic-Seizure-Classification
Accurate prediction of epileptic seizures allows patients to take preventive measures in advance to avoid possible injuries. In this work, a novel convolutional neural network (CNN) is proposed to analyze time, frequency, and channel information of e
lectroencephalography (EEG) signals. The model uses three-dimensional (3D) kernels to facilitate the feature extraction over the three dimensions. The application of multiscale dilated convolution enables the 3D kernel to have more flexible receptive fields. The proposed CNN model is evaluated with the CHB-MIT EEG database, the experimental results indicate that our model outperforms the existing state-of-the-art, achieves 80.5% accuracy, 85.8% sensitivity and 75.1% specificity.
We propose a computationally efficient algorithm for seizure detection. Instead of using a purely data-driven approach, we develop a hybrid model-based/data-driven method, combining convolutional neural networks with factor graph inference. On the CH
B-MIT dataset, we demonstrate that the proposed method can generalize well in a 6 fold leave-4-patientout evaluation. Moreover, it is shown that our algorithm can achieve as much as 5% absolute improvement in performance compared to previous data-driven methods. This is achieved while the computational complexity of the proposed technique is a fraction of the complexity of prior work, making it suitable for real-time seizure detection.
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