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تسجيل مستخدم جديدتخطيط العلاج المبني على الحسابات الشبه الحقيقية السريعة 2.0: نظام كامل ومرن لتخطيط العلاج لتطبيقات العلاج المحيط
RapidBrachyMCTPS 2.0: A Comprehensive and Flexible Monte Carlo-Based Treatment Planning System for Brachytherapy Applications
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Harry Glickman
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توصلنا سابقا إلى RapidBrachyMCTPS، وهي مجموعة أدوات تخطيط العلاج بالبراخيثرافيا تتضمن واجهة مستخدم رسومية (GUI) ومحرك حساب الجرعة المونت كارلو (MC) مبني على Geant4. يصف هذا العمل الأدوات التي تمت إضافتها حديثًا إلى RapidBrachyMCTPS، بحيث يصبح التطبيق الوحيد لتخطيط العلاج بالبراخيثرافيا المستند إلى MC. تضمن التغييرات الملحوظة استيرادًا ووضعًا محدثًا للمطبوعات، وأدوات التحيز في ثلاثة أبعاد، وخوارزميات تحسين الجرعة المحدثة أيضًا، بإضافة إلى تحسين موقع الإقامة ووقت الإقامة، كما يتم تحسين زوايا الدرع الدوراني في البراخيثرافيا المعدلة بالشدة. تم التحقق من الوحدات الرئيسية لـ RapidBrachyMCTPS بما في ذلك استيراد DICOM، استيراد ووضع المطبوعات، التحيز، تعيين المواد، تحديد المصدر، إعادة بناء الكاتيتر، توليد EGSphant، والتفاعل مع الرمز MC، وأدوات تحسين وتحليل الجرعة. تم تصميم حالتين مرضية للتوضيح من هذه المبادئ، مما يوضح التحكم والمرونة التي يقدمها RapidBrachyMCTPS لجميع خطوات طريق التخطيط العلاجي. يصبح RapidBrachyMCTPS الآن تطبيقًا مستقلًا لتخطيط العلاج بالبراخيثرافيا، ويوفر واجهة مستخدم سهلة الاستخدام للوصول إلى حسابات MC القوية. يمكن استخدامه للتحقق من توزيعات الجرعة من أنظمة تخطيط العلاج السريري أو الخوارزميات الحسابية المستندة إلى النموذج، ويناسب أيضًا اختبار تركيبات جديدة من المصادر الإشعاعية والمطبوعات، وخاصة التي محمية بمواد ذات ذروة عالية.
We have previously described RapidBrachyMCTPS, a brachytherapy treatment planning toolkit consisting of a graphical user interface (GUI) and a Geant4-based Monte Carlo (MC) dose calculation engine. This work describes the tools that have recently been added to RapidBrachyMCTPS, such that it now serves as the first stand-alone application for MC-based brachytherapy treatment planning. Notable changes include updated applicator import and positioning, three-plane contouring tools, and updated dose optimization algorithms that, in addition to optimizing dwell position and dwell time, also optimize the rotating shield angles in intensity modulated brachytherapy. The main modules of RapidBrachyMCTPS were validated including DICOM import, applicator import and positioning, contouring, material assignment, source specification, catheter reconstruction, EGSphant generation, interface with the MC code, and dose optimization and analysis tools. Two patient cases were simulated to demonstrate these principles, illustrating the control and flexibility offered by RapidBrachyMCTPS for all steps of the treatment planning pathway. RapidBrachyMCTPS is now a stand-alone application for brachytherapy treatment planning, and offers a user-friendly interface to access powerful MC calculations. It can be used to validate dose distributions from clinical treatment planning systems or model-based dose calculation algorithms, and is also well suited to testing novel combinations of radiation sources and applicators, especially those shielded with high-Z materials.
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