اشترك بالحزمة الذهبية واحصل على وصول غير محدود شمرا أكاديميا
تسجيل مستخدم جديدStructural diverseness of neurons between brain areas and between cases
613
0
0.0
(
0
)
اسأل ChatGPT حول البحث
ﻻ يوجد ملخص باللغة العربية
The cerebral cortex is composed of multiple cortical areas that exert a wide variety of brain functions. Although human brain neurons are genetically and areally mosaic, the three-dimensional structural differences between neurons in different brain areas or between the neurons of different individuals have not been delineated. Here, we report a nanometer-scale geometric analysis of brain tissues of the superior temporal gyrus of 4 schizophrenia and 4 control cases by using synchrotron radiation nanotomography. The results of the analysis and a comparison with results for the anterior cingulate cortex indicated that 1) neuron structures are dissimilar between brain areas and that 2) the dissimilarity varies from case to case. The structural diverseness was mainly observed in terms of the neurite curvature that inversely correlates with the diameters of the neurites and spines. The analysis also revealed the geometric differences between the neurons of the schizophrenia and control cases, suggesting that neuron structure is associated with brain function. The area dependency of the neuron structure and its diverseness between individuals should represent the individuality of brain functions.
قيم البحث
اقرأ أيضاً
Neurons within a population are strongly correlated, but how to simply capture these correlations is still a matter of debate. Recent studies have shown that the activity of each cell is influenced by the population rate, defined as the summed activi
ty of all neurons in the population. However, an explicit, tractable model for these interactions is still lacking. Here we build a probabilistic model of population activity that reproduces the firing rate of each cell, the distribution of the population rate, and the linear coupling between them. This model is tractable, meaning that its parameters can be learned in a few seconds on a standard computer even for large population recordings. We inferred our model for a population of 160 neurons in the salamander retina. In this population, single-cell firing rates depended in unexpected ways on the population rate. In particular, some cells had a preferred population rate at which they were most likely to fire. These complex dependencies could not be explained by a linear coupling between the cell and the population rate. We designed a more general, still tractable model that could fully account for these non-linear dependencies. We thus provide a simple and computationally tractable way to learn models that reproduce the dependence of each neuron on the population rate.
Advances in optical neuroimaging techniques now allow neural activity to be recorded with cellular resolution in awake and behaving animals. Brain motion in these recordings pose a unique challenge. The location of individual neurons must be tracked
in 3D over time to accurately extract single neuron activity traces. Recordings from small invertebrates like C. elegans are especially challenging because they undergo very large brain motion and deformation during animal movement. Here we present an automated computer vision pipeline to reliably track populations of neurons with single neuron resolution in the brain of a freely moving C. elegans undergoing large motion and deformation. 3D volumetric fluorescent images of the animals brain are straightened, aligned and registered, and the locations of neurons in the images are found via segmentation. Each neuron is then assigned an identity using a new time-independent machine-learning approach we call Neuron Registration Vector Encoding. In this approach, non-rigid point-set registration is used to match each segmented neuron in each volume with a set of reference volumes taken from throughout the recording. The way each neuron matches with the references defines a feature vector which is clustered to assign an identity to each neuron in each volume. Finally, thin-plate spline interpolation is used to correct errors in segmentation and check consistency of assigned identities. The Neuron Registration Vector Encoding approach proposed here is uniquely well suited for tracking neurons in brains undergoing large deformations. When applied to whole-brain calcium imaging recordings in freely moving C. elegans, this analysis pipeline located 150 neurons for the duration of an 8 minute recording and consistently found more neurons more quickly than manual or semi-automated approaches.
We show that dynamical gain modulation of neurons stimulus response is described as an information-theoretic cycle that generates entropy associated with the stimulus-related activity from entropy produced by the modulation. To articulate this theory
, we describe stimulus-evoked activity of a neural population based on the maximum entropy principle with constraints on two types of overlapping activities, one that is controlled by stimulus conditions and the other, termed internal activity, that is regulated internally in an organism. We demonstrate that modulation of the internal activity realises gain control of stimulus response, and controls stimulus information. A cycle of neural dynamics is then introduced to model information processing by the neurons during which the stimulus information is dynamically enhanced by the internal gain-modulation mechanism. Based on the conservation law for entropy production, we demonstrate that the cycle generates entropy ascribed to the stimulus-related activity using entropy supplied by the internal mechanism, analogously to a heat engine that produces work from heat. We provide an efficient cycle that achieves the highest entropic efficiency to retain the stimulus information. The theory allows us to quantify efficiency of the internal computation and its theoretical limit.
The anatomically layered structure of a human brain results in leveled functions. In all these levels of different functions, comparison, feedback and imitation are the universal and crucial mechanisms. Languages, symbols and tools play key roles in
the development of human brain and entire civilization.
Recent advances in neuroscience data acquisition allow for the simultaneous recording of large populations of neurons across multiple brain areas while subjects perform complex cognitive tasks. Interpreting these data requires us to index how task-re
levant information is shared across brain regions, but this is often confounded by the mixing of different task parameters at the single neuron level. Here, inspired by a method developed for a single brain area, we introduce a new technique for demixing variables across multiple brain areas, called demixed shared component analysis (dSCA). dSCA decomposes population activity into a few components, such that the shared components capture the maximum amount of shared information across brain regions while also depending on relevant task parameters. This yields interpretable components that express which variables are shared between different brain regions and when this information is shared across time. To illustrate our method, we reanalyze two datasets recorded during decision-making tasks in rodents and macaques. We find that dSCA provides new insights into the shared computation between different brain areas in these datasets, relating to several different aspects of decision formation.
سجل دخول لتتمكن من نشر تعليقات
التعليقات
جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
