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SPECT systems using pinhole apertures permit radiolabeled molecular distributions to be imaged in vivo in small animals. Nevertheless studying cardiovascular diseases by means of small animal models is very challenging. Specifically, submillimeter spatial resolution, good energy resolution and high sensitivity are required. We designed what we consider the optimal radionuclide detector system for this task. It should allow studying both detection of unstable atherosclerotic plaques and monitoring the effect of therapies. Using mice is particularly challenging in situations that require several intravenous injections of radiotracers, possibly for week or even months, in chronically ill animals. Thus, alternative routes of delivering the radiotracer in tail vein should be investigated. In this study we have performed preliminary measurements of detection of atherosclerotic plaques in genetically modified mice with high-resolution prototype detector. We have also evaluated the feasibility of assessing left ventricular perfusion by intraperitoneal delivering of MIBI-Tc in healthy mice.
Computer tomography is one of the most promising new methods to image abnormal tissues inside the human body. Tomography is also used to position the patient accurately before radiation therapy. Hadron therapy for treating cancer has become one of th
We report on high-efficiency superconducting nanowire single-photon detectors based on amorphous WSi and optimized at 1064 nm. At an operating temperature of 1.8 K, we demonstrated a 93% system detection efficiency at this wavelength with a dark nois
We present the first evaluation of a recently developed silicon-strip detector for photon-counting dual-energy breast tomosynthesis. The detector is well suited for tomosynthesis with high dose efficiency and intrinsic scatter rejection. A method was
We probe the local detection efficiency in a nanowire superconducting single-photon detector along the cross-section of the wire with a spatial resolution of 10 nm. We experimentally find a strong variation in the local detection efficiency of the de
We discuss a novel approach to the problem of creating a photon number resolving detector using the giant Kerr nonlinearities available in electromagnetically induced transparency. Our scheme can implement a photon number quantum non-demolition measu