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We study structural changes of adaptive networks in the co-evolutionary susceptible-infected-susceptible (SIS) network model along its phase transition. We clarify to what extent these changes can be used as early-warning signs for the transition at the critical infection rate $lambda_c$ at which the network collapses and the system disintegrates. We analyze the interplay between topology and node-state dynamics near criticality. Several network measures exhibit clear maxima or minima close to the critical threshold that could potentially serve as early-warning signs. These measures include the $SI$ link density, triplet densities, clustering, assortativity and the eigenvalue gap. For the $SI$ link density and triplet densities the maximum is found to originate from the co-existence of two power laws. Other network quantities, such as the degree, the branching ratio, or the harmonic mean distance, show scaling with a singularity at $lambda=0$ and not at $lambda_c$, which means that they are incapable of detecting the transition.
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