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Role of the membrane for mechanosensing by tethered channels

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 نشر من قبل Benedikt Sabass
 تاريخ النشر 2016
  مجال البحث فيزياء
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Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the non-trivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify force sensitivity of tethered channels.



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