ترغب بنشر مسار تعليمي؟ اضغط هنا

The zero-patient problem with noisy observations

131   0   0.0 ( 0 )
 نشر من قبل Alfredo Braunstein
 تاريخ النشر 2014
  مجال البحث علم الأحياء فيزياء
والبحث باللغة English




اسأل ChatGPT حول البحث

A Belief Propagation approach has been recently proposed for the zero-patient problem in a SIR epidemics. The zero-patient problem consists in finding the initial source of an epidemic outbreak given observations at a later time. In this work, we study a harder but related inference problem, in which observations are noisy and there is confusion between observed states. In addition to studying the zero-patient problem, we also tackle the problem of completing and correcting the observations possibly finding undiscovered infected individuals and false test results. Moreover, we devise a set of equations, based on the variational expression of the Bethe free energy, to find the zero patient along with maximum-likelihood epidemic parameters. We show, by means of simulated epidemics, how this method is able to infer details on the past history of an epidemic outbreak based solely on the topology of the contact network and a single snapshot of partial and noisy observations.



قيم البحث

اقرأ أيضاً

We develop theoretical equivalences between stochastic and deterministic models for populations of individual cells stratified by age. Specifically, we develop a hierarchical system of equations describing the full dynamics of an age-structured multi -stage Markov process for approximating cell cycle time distributions. We further demonstrate that the resulting mean behaviour is equivalent, over large timescales, to the classical McKendrick-von Foerster integro-partial differential equation. We conclude by extending this framework to a spatial context, facilitating the modelling of travelling wave phenomena and cell-mediated pattern formation. More generally, this methodology may be extended to myriad reaction-diffusion processes for which the age of individuals is relevant to the dynamics.
Many systems may switch to an undesired state due to internal failures or external perturbations, of which critical transitions toward degraded ecosystem states are a prominent example. Resilience restoration focuses on the ability of spatially-exten ded systems and the required time to recover to their desired states under stochastic environmental conditions. While mean-field approaches may guide recovery strategies by indicating the conditions needed to destabilize undesired states, these approaches are not accurately capturing the transition process toward the desired state of spatially-extended systems in stochastic environments. The difficulty is rooted in the lack of mathematical tools to analyze systems with high dimensionality, nonlinearity, and stochastic effects. We bridge this gap by developing new mathematical tools that employ nucleation theory in spatially-embedded systems to advance resilience restoration. We examine our approach on systems following mutualistic dynamics and diffusion models, finding that systems may exhibit single-cluster or multi-cluster phases depending on their sizes and noise strengths, and also construct a new scaling law governing the restoration time for arbitrary system size and noise strength in two-dimensional systems. This approach is not limited to ecosystems and has applications in various dynamical systems, from biology to infrastructural systems.
Food webs represent the set of consumer-resource interactions among a set of species that co-occur in a habitat, but most food web studies have omitted parasites and their interactions. Recent studies have provided conflicting evidence on whether inc luding parasites changes food web structure, with some suggesting that parasitic interactions are structurally distinct from those among free-living species while others claim the opposite. Here, we describe a principled method for understanding food web structure that combines an efficient optimization algorithm from statistical physics called parallel tempering with a probabilistic generalization of the empirically well-supported food web niche model. This generative model approach allows us to rigorously estimate the degree to which interactions that involve parasites are statistically distinguishable from interactions among free-living species, whether parasite niches behave similarly to free-living niches, and the degree to which existing hypotheses about food web structure are naturally recovered. We apply this method to the well-studied Flensburg Fjord food web and show that while predation on parasites, concomitant predation of parasites, and parasitic intraguild trophic interactions are largely indistinguishable from free-living predation interactions, parasite-host interactions are different. These results provide a powerful new tool for evaluating the impact of classes of species and interactions on food web structure to shed new light on the roles of parasites in food webs
92 - William Bialek 2020
There is growing effort in the physics of behavior that aims at complete quantitative characterization of animal movements under more complex, naturalistic conditions. One reaction to the resulting explosion of data is the search for low dimensional structure. Here I try to define more clearly what we mean by the dimensionality of behavior, where observable behavior may consist either of continuous trajectories or sequences of discrete states. This discussion also serves to isolate situations in which the dimensionality of behavior is effectively infinite. I conclude with some more general perspectives about the importance of quantitative phenomenology.
Finding ways to overcome the temptation to exploit one another is still a challenge in behavioural sciences. In the framework of evolutionary game theory, punishing strategies are frequently used to promote cooperation in competitive environments. He re, we introduce altruistic punishers in the spatial public goods game. This strategy acts as a cooperator in the absence of defectors, otherwise it will punish all defectors in their vicinity while bearing a cost to do so. We observe three distinct behaviours in our model: i) in the absence of punishers, cooperators (who dont punish defectors) are driven to extinction by defectors for most parameter values; ii) clusters of punishers thrive by sharing the punishment costs when these are low iii) for higher punishment costs, punishers, when alone, are subject to exploitation but in the presence of cooperators can form a symbiotic spatial structure that benefits both. This last observation is our main finding since neither cooperation nor punishment alone can survive the defector strategy in this parameter region and the specificity of the symbiotic spatial configuration shows that lattice topology plays a central role in sustaining cooperation. Results were obtained by means of Monte Carlo simulations on a square lattice and subsequently confirmed by a pairwise comparison of different strategies payoffs in diverse group compositions, leading to a phase diagram of the possible states.
التعليقات
جاري جلب التعليقات جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا