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The diffusion approximation of the Wright-Fisher model of population genetics leads to partial differentiable equations, the so-called Kolmogorov equations, with an operator that degenerates at the boundary. Standard tools do not apply, and in fact, solutions lack regularity properties. In this paper, we develop a regularising blow-up scheme for a certain class of solutions of the backward Kolmogorov equation, the iteratively extended global solutions presented in cite{THJ5}, and establish their uniqueness. As the model describes the random genetic drift of several alleles at the same locus from a backward perspective, the singularities result from the loss of an allele. While in an analytical approach, this causes substantial difficulties, from a biological or geometric perspective, this is a natural process that can be analyzed in detail. The presented scheme regularises the solution via a tailored successive transformation of the domain.
We develop an iterative global solution scheme for the backward Kolmogorov equation of the diffusion approximation of the Wright-Fisher model of population genetics. That model describes the random genetic drift of several alleles at the same locus i
We develop a global and hierarchical scheme for the forward Kolmogorov (Fokker-Planck) equation of the diffusion approximation of the Wright-Fisher model of population genetics. That model describes the random genetic drift of several alleles at the
We develop a general solution for the Fokker-Planck (Kolomogorov) equation representing the diffusion limit of the Wright-Fisher model of random genetic drift for an arbitrary number of alleles at a single locus. From this solution, we can readily de
The Wright-Fisher family of diffusion processes is a widely used class of evolutionary models. However, simulation is difficult because there is no known closed-form formula for its transition function. In this article we demonstrate that it is in fa
We show that the Hunter-Saxton equation $u_t+uu_x=frac14big(int_{-infty}^x dmu(t,z)- int^{infty}_x dmu(t,z)big)$ and $mu_t+(umu)_x=0$ has a unique, global, weak, and conservative solution $(u,mu)$ of the Cauchy problem on the line.