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We examine the properties of a recently proposed model for antigenic variation in malaria which incorporates multiple epitopes and both long-lasting and transient immune responses. We show that in the case of a vanishing decay rate for the long-lasting immune response, the system exhibits the so-called bifurcations without parameters due to the existence of a hypersurface of equilibria in the phase space. When the decay rate of the long-lasting immune response is different from zero, the hypersurface of equilibria degenerates, and a multitude of other steady states are born, many of which are related by a permutation symmetry of the system. The robustness of the fully symmetric state of the system was investigated by means of numerical computation of transverse Lyapunov exponents. The results of this exercise indicate that for a vanishing decay of long-lasting immune response, the fully symmetric state is not robust in the substantial part of the parameter space, and instead all variants develop their own temporal dynamics contributing to the overall time evolution. At the same time, if the decay rate of the long-lasting immune response is increased, the fully symmetric state can become robust provided the growth rate of the long-lasting immune response is rapid.
An epidemic model with distributed time delay is derived to describe the dynamics of infectious diseases with varying immunity. It is shown that solutions are always positive, and the model has at most two steady states: disease-free and endemic. It
In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen. Using the example of a model of antigenic variation in malaria, w
We report on transcritical bifurcations of periodic orbits in non-integrable two-dimensional Hamiltonian systems. We discuss their existence criteria and some of their properties using a recent mathematical description of transcritical bifurcations i
We consider networks formed from two populations of identical oscillators, with uniform strength all-to-all coupling within populations, and also between populations, with a different strength. Such systems are known to support chimera states in whic
This report investigates the dynamical stability conjectures of Palis and Smale, and Pugh and Shub from the standpoint of numerical observation and lays the foundation for a stability conjecture. As the dimension of a dissipative dynamical system is