اشترك بالحزمة الذهبية واحصل على وصول غير محدود شمرا أكاديميا
تسجيل مستخدم جديدWave-train induced unpinning of weakly anchored vortices in excitable media
201
0
0.0
(
0
)
اسأل ChatGPT حول البحث
ﻻ يوجد ملخص باللغة العربية
A free vortex in excitable media can be displaced and removed by a wave-train. However, simple physical arguments suggest that vortices anchored to large inexcitable obstacles cannot be removed similarly. We show that unpinning of vortices attached to obstacles smaller than the core radius of the free vortex is possible through pacing. The wave-train frequency necessary for unpinning increases with the obstacle size and we present a geometric explanation of this dependence. Our model-independent results suggest that decreasing excitability of the medium can facilitate pacing-induced removal of vortices in cardiac tissue.
قيم البحث
اقرأ أيضاً
Amoeboid cell migration is characterized by frequent changes of the direction of motion and resembles a persistent random walk on long time scales. Although it is well known that cell migration is typically driven by the actin cytoskeleton, the cause
of this migratory behavior remains poorly understood. We analyze the spontaneous dynamics of actin assembly due to nucleation promoting factors, where actin filaments lead to an inactivation of the nucleators. We show that this system exhibits excitable dynamics and can spontaneously generate waves, which we analyse in detail. By using a phase-field approach, we show that these waves can generate cellular random walks. We explore how the characteristics of these persistent random walks depend on the parameters governing the actin-nucleator dynamics. In particular, we find that the effective diffusion constant and the persistence time depend strongly on the speed of filament assembly and the rate of nucleator inactivation. Our findings point to a deterministic origin of the random walk behavior and suggest that cells could adapt their migration pattern by modifying the pool of available actin.
When propagated action potentials in cardiac tissue interact with local heterogeneities, reflected waves can sometimes be induced. These reflected waves have been associated with the onset of cardiac arrhythmias, and while their generation is not wel
l understood, their existence is linked to that of one-dimensional (1D) spiral waves. Thus, understanding the existence and stability of 1D spirals plays a crucial role in determining the likelihood of the unwanted reflected pulses. Mathematically, we probe these issues by viewing the 1D spiral as a time-periodic antisymmetric source defect. Through a combination of direct numerical simulation and continuation methods, we investigate existence and stability of a 1D spiral wave in a qualitative ionic model to determine how the systems propensity for reflections are influenced by system parameters. Our results support and extend a previous hypothesis that the 1D spiral is an unstable periodic orbit that emerges through a global rearrangement of heteroclinic orbits and we identify key parameters and physiological processes that promote and deter reflection behavior.
We develop a theory for the emergence of global firings in non-identical excitable systems subject to noise. Three different dynamical regimes arise: sub-threshold motion, where all elements remain confined near the fixed point; coherent pulsations,
where a macroscopic fraction fire simultaneously; and incoherent pulsations, where units fire in a disordered fashion. We also show that the mechanism for global firing is generic: it arises from degradation of entrainment originated either by noise or by diversity.
A thring is a recent addition to the zoo of spiral wave phenomena found in excitable media and consists of a scroll ring that is threaded by a pair of counter-rotating scroll waves. This arrangement behaves like a particle that swims through the medi
um. Here, we present the first results on the dynamics, interaction and collective behaviour of several thrings via numerical simulation of the reaction-diffusion equations that model thrings created in chemical experiments. We reveal an attraction between two thrings that leads to a stable bound pair that thwarts their individual locomotion. Furthermore, such a pair emits waves at a higher frequency than a single thring, which protects the pair from the advances of any other thring and rules out the formation of a triplet bound state. As a result, the long-term evolution of a colony of thrings ultimately yields an unusual frozen nonequilibrium state consisting of a collection of pairs accompanied by isolated thrings that are inhibited from further motion by the waves emanating from the pairs.
In this paper we present the results of parallel numerical computations of the long-term dynamics of linked vortex filaments in a three-dimensional FitzHugh-Nagumo excitable medium. In particular, we study all torus links with no more than 12 crossin
gs and identify a timescale over which the dynamics is regular in the sense that each link is well-described by a spinning rigid conformation of fixed size that propagates at constant speed along the axis of rotation. We compute the properties of these links and demonstrate that they have a simple dependence on the crossing number of the link for a fixed number of link components. Furthermore, we find that instabilities that exist over longer timescales in the bulk can be removed by boundary interactions that yield stable torus links which settle snugly at the medium boundary. The Borromean rings are used as an example of a non-torus link to demonstrate both the irregular tumbling dynamics that arises in the bulk and its suppression by a tight confining medium. Finally, we investigate the collision of torus links and reveal that this produces a complicated wrestling motion where one torus link can eventually dominate over the other by pushing it into the boundary of the medium.
سجل دخول لتتمكن من نشر تعليقات
التعليقات
جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
