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تسجيل مستخدم جديدTwo-strain competition in quasi-neutral stochastic disease dynamics
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We develop a new perturbation method for studying quasi-neutral competition in a broad class of stochastic competition models, and apply it to the analysis of fixation of competing strains in two epidemic models. The first model is a two-strain generalization of the stochastic Susceptible-Infected-Susceptible (SIS) model. Here we extend previous results due to Parsons and Quince (2007), Parsons et al (2008) and Lin, Kim and Doering (2012). The second model, a two-strain generalization of the stochastic Susceptible-Infected-Recovered (SIR) model with population turnover, has not been studied previously. In each of the two models, when the basic reproduction numbers of the two strains are identical, a system with an infinite population size approaches a point on the deterministic coexistence line (CL): a straight line of fixed points in the phase space of sub-population sizes. Shot noise drives one of the strain populations to fixation, and the other to extinction, on a time scale proportional to the total population size. Our perturbation method explicitly tracks the dynamics of the probability distribution of the sub-populations in the vicinity of the CL. We argue that, whereas the slow strain has a competitive advantage for mathematically typical initial conditions, it is the fast strain that is more likely to win in the important situation when a few infectives of both strains are introduced into a susceptible population.
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