In this paper, by introducing a new user similarity index base on the diffusion process, we propose a modified collaborative filtering (MCF) algorithm, which has remarkably higher accuracy than the standard collaborative filtering. In the proposed al
gorithm, the degree correlation between users and objects is taken into account and embedded into the similarity index by a tunable parameter. The numerical simulation on a benchmark data set shows that the algorithmic accuracy of the MCF, measured by the average ranking score, is further improved by 18.19% in the optimal case. In addition, two significant criteria of algorithmic performance, diversity and popularity, are also taken into account. Numerical results show that the presented algorithm can provide more diverse and less popular recommendations, for example, when the recommendation list contains 10 objects, the diversity, measured by the hamming distance, is improved by 21.90%.
The architecture of biological networks has been reported to exhibit high level of modularity, and to some extent, topological modules of networks overlap with known functional modules. However, how the modular topology of the molecular network affec
ts the evolution of its member proteins remains unclear. In this work, the functional and evolutionary modularity of Homo sapiens (H. sapiens) metabolic network were investigated from a topological point of view. Network decomposition shows that the metabolic network is organized in a highly modular core-periphery way, in which the core modules are tightly linked together and perform basic metabolism functions, whereas the periphery modules only interact with few modules and accomplish relatively independent and specialized functions. Moreover, over half of the modules exhibit co-evolutionary feature and belong to specific evolutionary ages. Peripheral modules tend to evolve more cohesively and faster than core modules do. The correlation between functional, evolutionary and topological modularity suggests that the evolutionary history and functional requirements of metabolic systems have been imprinted in the architecture of metabolic networks. Such systems level analysis could demonstrate how the evolution of genes may be placed in a genome-scale network context, giving a novel perspective on molecular evolution.
