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Intermediate/Extreme mass ratio inspiral (IMRI/EMRI) system provides a good tool to test the nature of gravity in strong field. We construct the self-force and use the self-force method to generate accurate waveform templates for IMRIS/EMRIs on quasi -elliptical orbits in Brans-Dicke theory. The extra monopole and dipole emissions in Brans-Dicke theory accelerate the orbital decay, so the observations of gravitational waves may place stronger constraint on Brans-Dicke theory. With a two-year observations of gravitational waves emitted from IMRIs/EMRIs with LISA, we can get the most stringent constraint on the Brans-Dicke coupling parameter $omega_0>10^5$.
We propose a novel high dynamic range (HDR) video reconstruction method with new tri-exposure quad-bayer sensors. Thanks to the larger number of exposure sets and their spatially uniform deployment over a frame, they are more robust to noise and spat ial artifacts than previous spatially varying exposure (SVE) HDR video methods. Nonetheless, the motion blur from longer exposures, the noise from short exposures, and inherent spatial artifacts of the SVE methods remain huge obstacles. Additionally, temporal coherence must be taken into account for the stability of video reconstruction. To tackle these challenges, we introduce a novel network architecture that divides-and-conquers these problems. In order to better adapt the network to the large dynamic range, we also propose LDR-reconstruction loss that takes equal contributions from both the highlighted and the shaded pixels of HDR frames. Through a series of comparisons and ablation studies, we show that the tri-exposure quad-bayer with our solution is more optimal to capture than previous reconstruction methods, particularly for the scenes with larger dynamic range and objects with motion.
Conformational transitions of flexible molecules, especially those driven by hydrophobic effects, tend to be hindered by desolvation barriers. For such transitions, it is thus important to characterize and understand the interplay between solvation a nd conformation. Using specialized molecular simulations, here we perform such a characterization for a hydrophobic polymer solvated in water. We find that an external potential, which unfavorably perturbs the polymer hydration waters, can trigger a coil-to-globule or collapse transition, and that the relative stabilities of the collapsed and extended states can be quantified by the strength of the requisite potential. Our results also provide mechanistic insights into the collapse transition, highlighting that polymer collapse proceeds through the formation of a sufficiently large non-polar cluster, and that collective water density fluctuations play an important role in stabilizing such a cluster. We also study the collapse of the hydrophobic polymer in octane, a non-polar solvent, and interestingly, we find that the mechanistic details of the transition are qualitatively similar to that in water.
Cybersecurity tools are increasingly automated with artificial intelligent (AI) capabilities to match the exponential scale of attacks, compensate for the relatively slower rate of training new cybersecurity talents, and improve of the accuracy and p erformance of both tools and users. However, the safe and appropriate usage of autonomous cyber attack tools - especially at the development stages for these tools - is still largely an unaddressed gap. Our survey of current literature and tools showed that most of the existing cyber range designs are mostly using manual tools and have not considered augmenting automated tools or the potential security issues caused by the tools. In other words, there is still room for a novel cyber range design which allow security researchers to safely deploy autonomous tools and perform automated tool testing if needed. In this paper, we introduce Pandora, a safe testing environment which allows security researchers and cyber range users to perform experiments on automated cyber attack tools that may have strong potential of usage and at the same time, a strong potential for risks. Unlike existing testbeds and cyber ranges which have direct compatibility with enterprise computer systems and the potential for risk propagation across the enterprise network, our test system is intentionally designed to be incompatible with enterprise real-world computing systems to reduce the risk of attack propagation into actual infrastructure. Our design also provides a tool to convert in-development automated cyber attack tools into to executable test binaries for validation and usage realistic enterprise system environments if required. Our experiments tested automated attack tools on our proposed system to validate the usability of our proposed environment. Our experiments also proved the safety of our environment by compatibility testing using simple malicious code.
Hydrophobic effects drive diverse aqueous assemblies, such as micelle formation or protein folding, wherein the solvent plays an important role. Consequently, characterizing the free energetics of solvent density fluctuations can lead to important in sights into these processes. Although techniques such as the indirect umbrella sampling (INDUS) method (Patel et al. J. Stat. Phys. 2011, 145, 265-275) can be used to characterize solvent fluctuations in static observation volumes of various sizes and shapes, characterizing how the solvent mediates inherently dynamic processes, such as self-assembly or conformational change, remains a challenge. In this work, we generalize the INDUS method to facilitate the enhanced sampling of solvent fluctuations in dynamical observation volumes, whose positions and shapes can evolve. We illustrate the usefulness of this generalization by characterizing water density fluctuations in dynamic volumes pertaining to the hydration of flexible solutes, the assembly of small hydrophobes, and conformational transitions in a model peptide. We also use the method to probe the dynamics of hard spheres.
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